A method for the treatment or prophylaxis of one or more conditions or disorders selected from the group consisting of physiological pain, diarrhea, urinary incontinence, mental illness, drug and alcohol addiction/overdose, lung edema, depressioysema, apnea, cognitive disorders and gastrointestinal disorders, comprising administration to a subject in need of such treatment or prophylaxis, of a diarylmethylpiperazine or piperidine opioid compound.

Delta Pharmaceuticals, Inc.

Opioid diarylmethylpiperazines and piperidines

A method of treating warm-blooded animals suffering from diarrhea, which method comprises the administration of particular 4-(aroylamino)piperidinebutanamide derivatives and compositions containing the same. Novel 4-(aroylamino)piperidinebutanamide derivatives.

Janssen Pharmaceutica

4-(aroylamino)piperidine-butanimide derivatives

(-)E-2-(3,4-dichlorocinnamyl)-1-cyclo-propylmethyl-piperidine of formula I: ##STR1## and its pharmaceutically acceptable salts, is useful for treating diarrhea in mammals. Also disclosed are pharmaceutical compositions, processes for preparing compounds of formula (I) and intermediates useful for preparing compounds of formula I.

piperidine/diarrhea

Opioid diarylmethylpiperazines and piperidines

4-(aroylamino)piperidine-butanimide derivatives

-E-2-(3,4-dichlorocinnamyl)-1-cyclopropylmethylpiperidine, and its antidiarrhoeal use

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