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piperidine/insult
Link salvestatakse lõikelauale
Leht 1 alates 22 tulemused
NK-1 receptor antagonists for the treatment of neuronal injury and stroke
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Logi sisse
The present invention relates to a method of treating or preventing a disorder selected from stroke, epilepsy, head trauma, spinal cord trauma, ischemic neuronal damage such as cerebral ischemic damage from stroke or vascular occlusion (e.cf, during open heart surgery), excitotoxic neuronal damage
4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists
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Logi sisse
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention is related to 4-substituted piperidine analogs, including hydroxypiperidine and tetrahydropyridine analogs, as well as novel intermediates of the 4-substituted analogs. The analogs are selectively active as antagonists of
2-substituted piperidine analogs and their use as subtype-selective NMDA receptor antagonists
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention is related to 2-substituted piperidine analogs. The analogs are selectively active as antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes. The invention is also directed to the use of 2-substituted piperidine analogs as
2-substituted piperidine analogs and their use as subtype-selective NMDA receptor antagonists
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention is related to 2-substituted piperidine analogs. The analogs are selectively active as antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes. The invention is also directed to the use of 2-substituted piperidine analogs as
4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention is related to 4-substituted piperidine analogs, including hydroxypiperidine and tetrahydropyridine analogs. The analogs are selectively active as antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes. The invention is also
Piperidine derivatives as subtype selective N-Methyl-D-Aspartate antagonists
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FIELD OF INVENTION
The invention relates to piperidine derivatives as N-Methyl-D-Aspartate (NMDA) antagonists useful in the treatment of diseases and disorders responsive to antagonism of NMDA receptors.
BACKGROUND OF THE INVENTION
Many of the physiological and pathophysiological effects of the
Substituted 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives for reducing ischaemic damage
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is the national stage of Application No. PCT/EP02/11371, filed Oct. 10, 2002, which application claims priority from EP 01203927.7 filed Oct. 15, 2001.
FIELD OF THE INVENTION
The present invention relates to
Ethanesulfonyl-piperidine derivatives
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Logi sisse
BACKGROUND OF THE INVENTION
Under pathological conditions of acute and chronic forms of neurodegeneration overactivation of NMDA receptors is a key event for triggering neuronal cell death. NMDA receptors are composed of members from two subunit families, namely NR-1 (8 different splice variants)
Substituted piperidines as soluble epdxide hydrolase inhibitors
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Logi sisse
BACKGROUND OF THE INVENTION
Pain is generally divided into nociceptive and neuropathic pain. Nociceptive pain stems from neural pathways in response to tissue damaging or potentially tissue damaging signals, and includes inflammatory pain. Neuropathic pain tends to relate to dysfunctions within the
Neuroprotective substituted piperidine compounds with activity as NMDA NR2B subtype selective antagonists
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FIELD OF INVENTION
The present invention is generally related to substituted piperidine compounds and more particularly to compounds with activity as NMDA receptor subtype selective blockers that have low activity as blockers of hERG potassium channels.
The present invention relates to the compound
Piperidine derivatives, their production and use
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Logi sisse
TECHNICAL FIELD
This invention relates to novel piperidines derivatives which are of value as a pharmaceutical.
BACKGROUND ART
Although there have been known various compounds exhibiting inhibitory activity on angiotensin converting enzyme, any compound with such activity having a moiety of
Piperidine derivatives
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
TECHNICAL FIELD
This invention relates to novel piperidine derivatives which are of value as a pharmaceutical.
BACKGROUND ART
Although there have been known various compounds exhibiting inhibitory activity on angiotensin converting enzyme, any compound with such activity having a moiety of
Piperidine derivatives
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
TECHNICAL FIELD
This invention relates to novel piperidine derivatives which are of value as a pharmaceutical.
BACKGROUND ART
Although there have been known various compounds exhibiting inhibitory activity on angiotensin converting enzyme, any compound with such activity having a moiety of
Piperidine-containing compounds and use thereof
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Logi sisse
TECHNICAL FIELD
The present invention relates to piperidine-containing compounds which is useful as medicaments, and use thereof. For more detail, the present invention relates to a method for preventing and/or treating a metabolic disease, cerebrovascular disease, etc., which comprises
Neuroprotective pharmaceutical composition containing stereoisomers of arylcyclohexylamines
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BACKGROUND OF THE INVENTION
Excitatory amino acids (EAA), such as L-glutamate and L-aspartate, are involved in both excitatory neurotransmission and synaptic plasticity in the central nervous system (CNS). Lockhart, et al., Brain Res. 630:32-40 (1993). EAAs, however, are also neurotoxic and have
Kõige täiuslikum ravimtaimede andmebaas, mida toetab teadus
- Töötab 55 keeles
- Taimsed ravimid, mida toetab teadus
- Maitsetaimede äratundmine pildi järgi
- Interaktiivne GPS-kaart - märgistage ürdid asukohas (varsti)
- Lugege oma otsinguga seotud teaduspublikatsioone
- Otsige ravimtaimi nende mõju järgi
- Korraldage oma huvisid ja hoidke end kursis uudisteuuringute, kliiniliste uuringute ja patentidega
Sisestage sümptom või haigus ja lugege ravimtaimede kohta, mis võivad aidata, tippige ürdi ja vaadake haigusi ja sümptomeid, mille vastu seda kasutatakse.
* Kogu teave põhineb avaldatud teaduslikel uuringutel
