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piperidine/vähk
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Methods for treatment of cancers using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
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1. FIELD OF THE INVENTION
This invention relates to methods of treating, preventing and/or managing specific cancers, and other diseases including, but not limited to, those associated with, or characterized by, undesired angiogenesis, by the administration of one or more immunomodulatory compounds
Methods of treating cancer using 3-(5-amino-2-methyl-4-oxo-4Hquinazolin-3-yl)-piperidine-2,6-dione
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1. FIELD OF THE INVENTION
Provided herein are methods of treating, preventing and/or managing cancers, which comprise administering to a patient 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable
Methods and compositions using 4-amino-2-(2,6-dioxo-piperidine-3-yl)-isoindoline-1,3-dione for treatment and management of central nervous system cancers
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1. FIELD
Provided herein are methods of treating, preventing and/or managing certain types of central nervous system cancers, and other diseases including, but not limited to, primary central nervous system lymphoma ("PCNSL"), primary vitreoretinal lymphoma ("PVRL"), intra-ocular lymphoma, central
Diarylalkyl piperidines useful as multi-drug resistant tumor agents
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BACKGROUND OF THE INVENTION
Effective tumor treatment is frequently thwarted by the lack of sensitivity of certain tumors to standard chemotherapeutic agents (intrinsic resistance) or by the ability of certain tumors to develop a lack of chemotherapeutic sensitivity during the course of treatment
Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention concerns piperidine-2,6-dione derivatives which are active as inhibitors of tumor necrosis factor released by cells, the preparation of these derivatives, as well as their application as pharmaceutically-active ingredients.
2.
Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors
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Logi sisse
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention concerns piperidine-2,6-dione derivatives which are active as inhibitors of tumor necrosis factor released by cells, the preparation of these derivatives, as well as their application as pharmaceutically-active ingredients.
2.
Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors
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Logi sisse
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention concerns piperidine-2,6-dione derivatives which are active as inhibitors of tumor necrosis factor released by cells, the preparation of these derivatives, as well as their application as pharmaceutically-active ingredients.
2.
Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors
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Logi sisse
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention concerns piperidine-2,6-dione derivatives which are active as inhibitors of tumor necrosis factor released by cells, the preparation of these derivatives, as well as their application as pharmaceutically-active ingredients.
2.
Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors
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Logi sisse
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention concerns piperidine-2,6-dione derivatives which are active as inhibitors of tumor necrosis factor released by cells, the preparation of these derivatives, as well as their application as pharmaceutically-active ingredients.
2.
3,5-dibenzoyl-4-phenyl-piperidine anti-cancer compounds
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Logi sisse
Provided are certain chemical entities that cause mitotic arrest and cell death and are useful in the treatment of cellular proliferative diseases, for example cancer.
Improvements in the specificity of agents used to treat cancer is of considerable interest. Reducing the side effects associated
Substituted indolo-piperidine compounds
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BACKGROUND OF THE INVENTION
Cancer is the second leading cause of death in the United States, exceeded only by heart disease. (Cancer Facts and Figures 2004, American Cancer Society, Inc.). Despite recent advances in cancer diagnosis and treatment, surgery and radiotherapy may be curative if a
Pyridyl piperidines
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FIELD OF THE INVENTION
The invention relates to a series of novel substituted pyridyl piperidine compounds that are useful in the treatment of hyperproliferative diseases such as cancer, as well as inflammatory or degenerative diseases, in mammals. Also encompassed by the present invention is the
Heteroaryl-substituted piperidines
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RELATED APPLICATIONS/PATENTS AND INCORPORATION BY REFERENCE
This application claims priority to German Patent Application Number 102007057718.6 filed Nov. 30, 2007, and German Patent Application Number 102008010221.0 filed Feb. 20, 2008, the entire contents each of which are incorporated herein by
Substituted piperidine compounds
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BACKGROUND OF THE INVENTION
Field of the Invention
The present disclosure provides substituted piperidines as SMYD protein inhibitors, such as SMYD3 and SMYD2 inhibitors, and therapeutic methods of treating conditions and diseases wherein inhibition of SMYD proteins such as SMYD3 and SMYD2 provides
Substituted piperidines as Par-1 antagonists
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The invention relates to novel substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders and tumour
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