prostaglandin/insult

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Norepinephrine Infusion During Cardiopulmonary Bypass

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Rationale 1.1. Vasoplegia and cardiac surgery: Vasoplegia Syndrome (VS), prevailing in about 20% of cardiac surgical procedures (1), is defined as low mean arterial pressure (MAP) with normal or high cardiac indices and which is resistant to treatment with the commonly used vasopressors. (2,3)

The Effect of Adding Lubiprostone to Standard Large-Volume PEG-ELS on The Quality of Inpatient Colonoscopy Preparation

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2. INTRODUCTION AND BACKGROUND 2.1. Study rationale and aim An excellent bowel preparation is crucial to perform a high-quality colonoscopy and essential to visualize the entire colonic mucosa and to increase the safety of therapeutic maneuvers. Prior studies revealed that inpatient setting was

the Effect of WBPC on Subacute Stroke Patients

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So the investigators will recruit subacute stroke patients as our subjects. The patient who is booked to our rehabilitation ward for further rehabilitation programs is eligible for our study. the investigators will recruit 30 patients, and randomize them to experimental and control group. This study

Migraine Relief After Patent Foramen Ovale Closure: a Single Center Analysis

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The Study will evaluate the results of approximately 100 subjects from a single center study registered in this trial. Subjects who experienced transient ischemic attack (TIA) or stroke with a clinical indication to PFO closure and symptomatic for migraine with/o aura are considered for a migraine

Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Elective Caesarean Section

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RESEARCH QUESTION Does intravenous Tranexamic Acid (TXA) 10mg/kg plus Oxytocin 5 International Units (IU) result in a lower incidence of primary postpartum haemorrhage compared to Oxytocin alone after elective caesarean section. RATIONALE FOR THE RESEARCH Postpartum haemorrhage (PPH) is a major

Topical 10 % Nifedipine Versus 5% Sildenafil in Secondary Raynaud

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Raynaud's phenomenon (RP) is an exaggerated vascular response characterized by at least biphasic change (pallor and cyanosis) in the skin color of the digits, induced by cold temperature or emotional stress, The prevalence varies from 3 to 5%. In primary RP, there is no evidence of a secondary cause

Cerebral Blood Flow During Propofol Anaesthesia

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Background General anaesthesia reduces blood pressure, but cerebral autoregulation is considered to maintain its blood flow if mean arterial pressure (MAP) is between 60-150 mmHg. Thus, vasoactive medication is administered to treat anaesthesia-induced hypotension if MAP decreases to below

Aspirin and Renal Disease Progression in Patients With Type 2 Diabetes

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Epidemiological data show that type 2 diabetes has an epidemic trend worldwide. The increase in food intake, the greater availability of refined grains and the reduction of physical activity had, in fact, negative effects in most areas. It is expected that the number of people suffering from

Daily Ginger Drinking and Platelet Function

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Herbal medicine products are dietary supplements that people take to improve their health. Many herbs have been used for a long time for claimed health benefits. They are sold as tablets, capsules, powders, beverages, extracts and fresh or dried plants. Herbal medicines have been associated with

Translational Study of the Effects of Neural Mobilization in Patients With Lomboisquiatalgia

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Translational study of the effects of Neural Mobilization in patients with lomboisquiatalgia The spinal nerve injury in humans often results in neuropathic pain characterized by spontaneous burning pain accompanied by allodynia and hyperalgesia [1]. These signs and symptoms occur in the continuous

Effect of Periodontitis on Bone Mineral Density in Postmenopausal Women

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Rapid estrogen level decline after menopause is associated with systemic bone loss in women leading to osteopenia/osteoporosis. Estrogen therapy (ET) improves bone mineral density (BMD) in postmenopausal women. Currently, ET has been associated with statistically significant increased risk of breast

Early Endoscopy for Acute Upper Gastrointestinal Bleeding in Acute Coronary Syndrome Patients

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Antiplatelet therapy is the cornerstone in the management of patients with ACS. Aspirin interferes platelet aggregation activity by decreasing thromboxane synthesis through inhibition of cyclo-oxygenase (COX) enzymes. Low-dose (75-325mg/day) aspirin has been demonstrated to reduce the risk of

Variability in Response to Non-steroidal Anti-inflammatory Drugs

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Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for the treatment of inflammatory pain. Pain is a highly subjective experience, and selecting an analgesic regimen that provides optimal pain relief for a specific patient can be challenging. Moreover, patients often express a

Lipidomics Screening of Celecoxib in ex Vivo Human Whole Blood Assay - Part B

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Logi sisse

Nonsteroidal anti-inflammatory drugs (NSAIDs), selective for inhibition of cyclooxygenase (COX)-2, alleviate pain and inflammation by suppressing COX-2-derived prostacyclin (PGI2) and prostaglandin (PG) E2 (1). However, eight placebo-controlled clinical trials have revealed that NSAIDs, designed to

The Effect of Connective Tissue Massage in Women With Primary Dysmenorrhoea

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Dysmenorrhoea has been defined painful menstruation. It is divided primary and secondary dysmenorrhoea according to the pathophysiology. Primary dysmenorrhoea is severe menstrual pain, occurs a short time after menarche and without pelvic pathology. Secondary dysmenorrhoea is severe menstrual pain

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