Analogues of prostaglandins A, E and F in which a phenyl moiety is attached to the C.sub.14 carbon atom are disclosed. Also disclosed are methods of preparing the analogues and starting materials. The compounds have the structural formula: ##STR1## in which J is methylene, R or S-hydroxymethylene or methine; L is methylene or methine and can be methine only when J is methine; M is carbonyl, R or S-hydroxymethylene; Q is ethylene, Z-vinylene or inter-phenylene; T is an alkoxy-carbonyl having from 2 to 3 carbon atoms inclusive, or carboxyl; and B is a loweralkyl of from 1 to 5 carbon atoms.The prostaglandin analogues of the present invention exhibit a separation of pharmacological activity. The analogues can be used for platelet aggregation (and Methyl 14-Phenyl-11.alpha.,15S-dihydroxy-9-oxoprost-13E-en-1-oate can be used for antagonism for smooth muscle stimulation) without the accompanying undesirable side effects of natural prostaglandins, e.g., flush, headache, abdominal cramps and nausea.

Miles Laboratories, Inc.

C.sub.14 Phenyl-substituted derivatives of prostaglandin analogues

A method is provided for inhibiting onset or treating migraine headaches by administering a thromboxane A.sub.2 receptor antagonist before of during the migraine which thromboxane A.sub.2 receptor antagonist is a 7-oxabicycloheptane prostaglandin analog.

E. R. Squibb &amp; Sons, Inc.

Method of inhibiting onset of or treating migraine headache using a thromboxane A2 receptor antagonist

The present invention provides for the treatment of primary headache disorders, particularly migraine, using antagonists of the EP.sub.4 receptor for prostaglandin E2. Particular EP.sub.4 receptor antagonists include azole compounds of formula (I): ##STR00001## wherein R.sup.1 is a group such as lower alkyl substituted with carboxy; R.sup.2 is hydrogen or lower alkyl, R.sup.3 and R.sup.4 are aryl optionally substituted with halogen, Q is ##STR00002## in which -A.sup.1- is a single bond or lower alkylene, ##STR00003## is a cyclo group, -A.sup.3- is a single bond or lower alkylene, and X is O, NH or S; or a salt or its solvate thereof.

Baxter; Gordon S.

Coleman; Robert A.

Tilford; Nicholas

Asterand UK Acquisition Limited

Method of identifying an inhibitor of the prostanoid EP4 receptor

The invention comprises a method for treatment of chronic and referred pain such as chronic headaches and migraine headaches, as well as pain of the upper back, neck and shoulders, and lower back pain using low power laser light. The source of such referred pain involves microscopic and macroscopic tears in the periosteal-osseous junctions of the upper vertebrae, the scapula, and the skull. These lesions stimulate the generation of histamines, kinins, bradykinins, prostaglandin, proteolytic enzymes, seratonin, and other substances which cause numerous localized autonomic reactions, such as muscle spasm, ischemia, local inflammation, edema, as well as generalized reactions such as increased blood pressure, photophobia, nausea, blurred vision, copious mucous flow of the nose and sinus, and the like. The muscle spasms are responsible for transmitting the pain sensation to other portions of the body, and the systemic reactions are often associated with migraine-type headaches. The sites of the periosteal-osseous lesions can be correlated directly with the distant locus of the referred pain sensation. The laser energy is directed to the sites of the lesions to cause an increase in lymphatic circulation at the site of the causative lesion in response to the laser energy. Laser energy delivered to the site results in increased blood circulation and cellular metabolism in the area, which promotes more rapid healing of the lesion.

prostaglandin/peavalu

C.sub.14 Phenyl-substituted derivatives of prostaglandin analogues

Method of inhibiting onset of or treating migraine headache using a thromboxane A2 receptor antagonist

Method of identifying an inhibitor of the prostanoid EP4 receptor

Method for pain relief using low power laser light

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