Participants randomized to consume either placebo beverage or tart cherry juice at beginning of the study followed by a 2 week washout then switch over to the alternate beverage. Approximately half of participants began study consuming placebo beverage and the other half TCJ.

Participants randomized to consume either placebo beverage or tart cherry juice at beginning of the study followed by a 2 week washout then switch over to the alternate beverage. Approximately half pf participants began study consuming placebo beverage and the other half TCJ.

Diabetes

Inflammation

Participants consumed placebo beverage for 4 weeks.

Placebo

Participants consumed tart cherry juice (8 ounces; 240 mL) per day for four weeks.

Tart cherry juice

Tart Cherry Juice and Chronic Disease Risk

Effect of Tart Cherry Juice on Inflammation and Dyslipidemia in Overweight and Obese Humans

high-sensitivity C-reactive protein (hsCRP), a marker of inflammation

Coded data will be available to relevant parties, e.g., investigators, recognized scientific bodies, etc. upon reasonable request within an adequate time frame. Emails may be directed to the Principal Investigator.

Keith Martin

Research Assistant Professor

University of Memphis

Arizona State University

Crossover Assignment In this study, the investigators recruited at-risk individuals who were overweight (25.0-29.9 kg/m2) and obese (> 30.0 kg/m2) and likely to exhibit one or more conditions associated with MetS. In this 10-week placebo-controlled 2 x 2 crossover dietary intervention, the investigators randomized participants to consume 240 mL (8 ounces) daily of either placebo (artificial cherry-flavored, anthocyanin-free beverage) or authentic TCJ for 4 weeks, followed by a 2-week washout period, then consumption of the alternate beverage for 4 weeks. Subsequently, the investigators determined the effect of TCJ in at-risk participants on markers of inflammation, glycemia, and lipidemia.

Placebo beverage was selected from commercially available, artificially flavored and colored fruit punches (Great Value fruit punch, Bentonville, AR) to match a closely as possible the color (red) of the TCJ.

Participants randomized to consume either placebo beverage or tart cherry juice at beginning of the study followed by a 4 week washout then switch over to the alternate beverage to account for timing and order effects.

Hyperuricemia

Insulin Resistance

Obesity

Participants randomized to consume for 4-weeks either placebo beverage or single-strength tart cherry juice at beginning of the study followed by a 4 week washout then switch over to the alternate beverage for 4 weeks to account for timing and order effects.

Tart Cherry Juice and Markers of Inflammation, CVD, and Diabetes

Anthocyanin-rich Tart Cherry Juice Consumption and Reduced Biomarkers of Inflammation, CVD, and Diabetes.

Hyperuricemia contributes to gout, a frequently occurring, complex rheumatologic form of inflammatory arthritis. The primary outcome measure of this study was serum uric acid and its reduction by TCJ consumption.

Elevated levels of hsCRP indicate inflammation. Serum levels of hsCRP as a secondary outcome measure were measured and the effect of TCJ in potentially lowering.

Increased serum triglycerides contribute to CVD and MetS. Serum TG was measured as a secondary outcome measure and the effect of TCJ in lowering levels.

Coded data will be available upon reasonable request as instructed by journal editors. Emails may be directed to the Principal Investigator.

In this study, the investigators recruited at-risk individuals who were overweight (25.0-29.9 kg/m2) and obese (> 30.0 kg/m2) and likely to exhibit one or more conditions associated with MetS. In this 12-week placebo-controlled 2 x 2 crossover dietary intervention, the investigators randomized participants to consume 240 mL (8 ounces) daily of either placebo (artificial cherry-flavored, anthocyanin-free beverage) or TCJ for 4 weeks, followed by a 4-week washout period, then consumption of the alternate beverage for 4 weeks. Subsequently, the investigators determined the effect of TCJ in at-risk participants on markers of uricemia, lipidemia, glycemia, and inflammation.

Placebo beverage was prepared in the ASU metabolic kitchen and matched for fructose and total carbohydrate concentrations as well as being artificially colored to match tart cherry juice.

130ml serving twice daily (immediately before breakfast and dinner) for 20 days.
Placebo composition: Water (100ml), Cherry Squash Concentrate (30ml), Citric Acid (1.5g), Maltodextrin (24.75g), Black Food Colouring (2ml).

130ml serving twice daily (immediately before breakfast and dinner) for 20 days.
MTCJ Composition: 100ml water and 30ml Montmorency tart cherry concentrate (Cherry Active, Sunbury, UK).

Healthy

Metabolic Syndrome

Montmorency Tart Cherry Juice

Effect of Cherry Juice on Fat Oxidation and Cardio-metabolic Markers

The Effect of Tart Cherry Juice Supplementation on Fat Oxidation, Body Composition and Cardio-Metabolic Markers With Cycling Exercise

Terun Desai

PhD Student

University of Hertfordshire

12 weeks of tart cherry juice taken in two doses of 240 ml per day.

12 weeks tart cherry juice taken in two doses of 240 ml per day.

Cardiovascular Diseases

Tart Cherry

Department of Nutrition, Food and Exercise Sciences, Center for Advancing Exercise and Nutrition Research on Aging, Florida State University

Tart Cherry, Metabolic Syndrome, and Cardiovascular Risk

Tart Cherry Improves Cardiovascular Risk Factors Associated With Metabolic Syndrome

By measuring brachial and aortic blood pressure at rest and during physiological stress (handgrip exercise and post-exercise muscle ischemia).

By measuring arterial stiffness and augmentation index at rest and during physiological stress (handgrip exercise and post-exercise muscle ischemia).

By measuring blood pressure variability and baroreflex sensitivity at rest and during physiological stress.

By measuring markers of endothelial function.

By measuring flow-mediated dilation in the brachial artery.

By measuring markers of oxidative stress.

By measuring fasting glucose, insulin, and homeostatic model assessments of insulin resistance, sensitivity, and beta cell function.

By measuring adhesion factors, lipid profiles, and atherogenic risk ratios.

By measuring fat mass and fat-free mass using dual-energy X-ray absorptiometry and anthropometrics.

prunus domestica/triglyceride

Tart Cherry Juice and Chronic Disease Risk

Tart Cherry Juice and Markers of Inflammation, CVD, and Diabetes

Effect of Cherry Juice on Fat Oxidation and Cardio-metabolic Markers

Tart Cherry, Metabolic Syndrome, and Cardiovascular Risk

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