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Leht 1 alates 49 tulemused
Effect of dietary nucleotides on intestinal repair in rats with experimental chronic diarrhea.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Nucleic acid synthesis in tissues of rapid growth is preferentially done using dietary purines and pyrimidines via the salvage pathway. In the case of a low protein intake, dietary nucleotides may be semiessential for cell replication of gut, lymphocytes, and bone marrow, and especially in those
Thiopurines inhibit bovine viral diarrhea virus production in a thiopurine methyltransferase-dependent manner.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
The family Flaviviridae comprises positive-strand RNA viral pathogens of humans and livestock with few treatment options. We have previously shown that azathioprine (AZA) has in vitro activity against bovine viral diarrhea virus (BVDV). While the mechanism of inhibition is unknown, AZA and related
Final results of a multicenter phase II study of the purine nucleoside phosphorylase (PNP) inhibitor forodesine in patients with advanced cutaneous T-cell lymphomas (CTCL) (Mycosis fungoides and Sézary syndrome).
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Logi sisse
BACKGROUND
Forodesine is a potent inhibitor of purine nucleoside phosphorylase (PNP) that leads to intracellular accumulation of deoxyguanosine triphosphate (dGTP) in T and B cells, resulting in apoptosis. Forodesine has demonstrated impressive antitumor activity in early phase clinical trials in
Final results of a multicenter phase II study of the purine nucleoside phosphorylase (PNP) inhibitor forodesine in patients with advanced cutaneous t-cell lymphomas (CTCL) (Mycosis fungoides and Sézary syndrome).
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Fludarabine phosphate: a synthetic purine antimetabolite with significant activity against lymphoid malignancies.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Fludarabine phosphate is the 2-fluoro, 5'-monophosphate derivative of vidarabine (ara-A) with the advantages of resistance to deamination by adenosine deaminase (ADA) and improved solubility. The mechanism of cytotoxic action of the compound appears to involve metabolic conversion to the active
The evolving role of pemetrexed (Alimta) in lung cancer.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Pemetrexed (Alimta; Eli Lilly and Co, Indianapolis, IN) is a multitargeted antifolate that inhibits several folate-dependent enzymes that play roles in purine and pyrimidine synthesis. The principal toxicities of pemetrexed are neutropenia, diarrhea, nausea/vomiting, mucositis, and skin rash. These
A phase II study of fixed dose rate gemcitabine in patients with relapsed müllerian tumors.
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Logi sisse
Gemcitabine (2',2'-difluorodeoxycytidine) is a novel purine analog with clinical activity against ovarian cancer. Accumulation of gemcitabine triphosphate (dFdCTP) increases in a linear fashion with prolonged infusions of gemcitabine, and there is a strong relationship between intracellular
Mycophenolate mofetil-related gastrointestinal mucosal injury in multivisceral transplantation.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Mycophenolate mofetil (MMF) has become an important and commonly used drug for maintenance immunosuppression therapy in recipients of all types of organ transplants. The drug is an antimetabolite that blocks the de novo pathway of purine synthesis. Although it selectively inhibits B- and
Mycophenolate mofetil for maintenance therapy in kidney transplantation.
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Logi sisse
Mycophenolate mofetil (MMF) is a new immunosuppressive drug that selectively inhibits de novo purine synthesis. It has been tested in three large double-blind controlled trials for the prevention of rejection in renal transplant patients. These studies indicate that the use of MMF dramatically
[Clinical trial of SM-108 in myeloproliferative disorders].
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
SM-108 (4-carbamoylimidazolium-5-olate) is a new purine antagonist which blocks IMP dehydrogenase, the key enzyme of de novo GMP biosynthesis. Eleven patients were entered into a clinical study of SM-108 for the treatment of myeloproliferative disorders. These included 10 cases of chronic
Treatment of psoriasis with oral mycophenolic acid.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Mycophenolic acid (MPA), an inhibitor of purine synthesis, was evaluated for its therapeutic and adverse effects in 29 patients with psoriasis. MPA was administered orally for at least 12 weeks, during which time the daily dose was increased from 1600 to 4800 mg depending on occurrence of adverse
[Listeriosis of central nervous system in patients with ulcerative colitis - case study].
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Logi sisse
In the recently an increase morbidity inflammatory bowel disease, including ulcerative colitis was observed. The use of purine analogs and their metabolites are associated with a higher incidence of infections in this group of patients. Listeriosis is an infectious disease caused by a relatively
Crude preparations of Dioon spinulosum dyer neurotoxicity: methylazoxymethanol produces petil mal seizures in susceptible individuals.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Dioon spinulosum is a cycad prepared as an alternative food and consumed by Chinantecos from Veracruz and Oaxaca, México. Whether Dioon spinulosum possesses neurotoxic properties is unknown, therefore, we used wistar rats receiving several regimens of D. spinulosum. Semi-liquid diarrhea followed the
Potential for developing purinergic drugs for gastrointestinal diseases.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Treatments for inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), functional dyspepsia, or motility disorders are not adequate, and purinergic drugs offer exciting new possibilities. Gastrointestinal symptoms that could be targeted for therapy include visceral pain, inflammatory pain,
Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethyl)adenine.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
The acyclic purine nucleoside analogue 9-(2-phosphonomethoxyethyl)adenine [PMEA; formerly referred to as 9-(2-phosphonylmethoxyethyl)adenine] is a potent and selective inhibitor of human immunodeficiency virus replication in vitro and of Moloney murine sarcoma virus-induced tumor formation in mice.
Kõige täiuslikum ravimtaimede andmebaas, mida toetab teadus
- Töötab 55 keeles
- Taimsed ravimid, mida toetab teadus
- Maitsetaimede äratundmine pildi järgi
- Interaktiivne GPS-kaart - märgistage ürdid asukohas (varsti)
- Lugege oma otsinguga seotud teaduspublikatsioone
- Otsige ravimtaimi nende mõju järgi
- Korraldage oma huvisid ja hoidke end kursis uudisteuuringute, kliiniliste uuringute ja patentidega
Sisestage sümptom või haigus ja lugege ravimtaimede kohta, mis võivad aidata, tippige ürdi ja vaadake haigusi ja sümptomeid, mille vastu seda kasutatakse.
* Kogu teave põhineb avaldatud teaduslikel uuringutel
