pyruvic acid/insult

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[Evaluation of pyruvic acid concentration in blood of patients with ischemic stroke in the earliest stage of the disease].

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Logi sisse

The aim of the study was the assessment of concentrations of pyruvic acid in the blood of patients with mild course and severe course of ischaemic stroke in the earliest stage of the disease. The subject of the study were 20 patients with a mild ischaemic stroke and 20 patients with a severe one on

[Lactic and pyruvic acid levels and lactate dehydrogenase activity in the blood in stroke].

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[The effect of polarizing mixture KIG (potassium + insulin + glucose) on some metabolites of glucose transformation in patients with ischemic stroke during the earliest period of illness].

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Logi sisse

The purpose of the study was to investigate the effect of polarizing mixture on the level of lactic and pyruvic acids in blood and cerebro-spinal fluid of patients with acute ischaemic stroke in the earliest phase of illness. The investigation was done in 20 patients with completed stroke and 16

[A case of MELAS with G13513A mutation presenting with chronic kidney disease long before stroke-like episodes].

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Logi sisse

The patient was a 35-year-old female with an 9-year history of chronic kidney disease awaiting renal transplantation. She was brought to hospital by ambulance due to a generalized convulsive seizure. Her consciousness remained disturbed after treatment for her seizure, and sensorineural deafness was

[Plasma metabonomics study of ischemic cerebral apoplexy rats treated with Tongsaimai pellets].

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Logi sisse

OBJECTIVE To observe abnormal metabolic changes caused by ischemic cerebral apoplexy and the regulating action of Tongsaimai pellets on abnormal metabolism by analyzing the change of small molecules in plasma of ischemic cerebral apoplexy rat. To find the potential biomarkers, and to explore

[Effectiveness of midazolam for L-arginine-resistant headaches during stroke-like episodes in MELAS: a case report].

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Logi sisse

A 14-year-old girl was referred to us with severe migraine-like headaches associated with vomiting and right homonymous hemianopsia. On admission, MRI examination showed high signals in the left occipital cortex and subcortex on T2-weighted images, without reduction of apparent diffusion coefficient

[Discriminative analysis in detecting cardiac insufficiency in myocardial infarct on the basis of the values of stroke volume and blood lactic acid level].

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Logi sisse

In 203 patients with large focal and transmural myocardial infarctions the cardiac output was studied by means of the dye dilution method, as well as the content of the lactic (Barker and Summerson's technique) and pyruvic acids (Travina's technique). Along with the growth of cardiac insufficiency a

Pyruvic acid prevents Cu2+/Zn2+-induced neurotoxicity by suppressing mitochondrial injury.

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Logi sisse

Zinc (Zn) is known as a co-factor for over 300 metalloproteins or enzymes, and has essential roles in many physiological functions. However, excessively high Zn concentrations are induced in pathological conditions such as interruption of blood flow in stroke or transient global ischemia-induced

Cytoprotection of pyruvic acid and reduced beta-nicotinamide adenine dinucleotide against hydrogen peroxide toxicity in neuroblastoma cells.

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Logi sisse

Elevated production of hydrogen peroxide (H2O2) in the central nervous system has been implicated in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease, ischemic reperfusion, stroke, and Alzheimer's disease. Pyruvic acid has a critical role in energy metabolism and

mtDNA nt3243 mutation, external ophthalmoplegia, and hypogonadism in an adolescent girl.

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Logi sisse

A 14-year-old girl presented with a 3-month history of easy fatigue and exercise intolerance, especially when climbing stairs. She had a mild ptosis and mild limitation of upward gaze. Her puberty was delayed, and she manifested hypogonadotrophic hypogonadism. Serum lactic and pyruvic acids were

Hyperpolarized MR imaging: neurologic applications of hyperpolarized metabolism.

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Logi sisse

Hyperpolarization is the general term for a method of enhancing the spin-polarization difference of populations of nuclei in a magnetic field. No less than 5 distinct techniques (dynamic nuclear polarization [DNP]; parahydrogen-induced polarization-parahydrogen and synthesis allow dramatically

[A case with late-onset MELAS with hallucination and delusion].

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Logi sisse

We report a 53-year-old male patient with late onset mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes(MELAS) with hallucination and delusion. The patient manifested various neurological symptoms including perceptive deafness, muscle weakness of limbs with loss of

Ethyl pyruvate: a novel anti-inflammatory agent.

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Logi sisse

Ethyl pyruvate (EP) is a simple derivative of the endogenous metabolite, pyruvic acid. Treatment with EP has been shown to improve survival and/or ameliorate organ dysfunction in a wide variety of preclinical models of critical illnesses, such as severe sepsis, acute respiratory distress syndrome,

The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds.

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Logi sisse

Pyruvate is an important metabolic intermediate, and also is an effective scavenger of hydrogen peroxide and other reactive oxygen species (ROS). Pharmacological administration of pyruvate has been shown to improve organ function in animal models of oxidant-mediated cellular injury. However,

Ethyl pyruvate.

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Logi sisse

OBJECTIVE Ethyl pyruvate is a simple derivative of the endogenous metabolite, pyruvic acid. Ethyl pyruvate was shown to ameliorate some of the structural and functional changes associated with mesenteric ischemia and reperfusion in rats. RESULTS Treatment with ethyl pyruvate has been shown to

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