Sarcopenia

Mitochondrial DNA

Tungs' Taichung MetroHarbour Hospital

Association of Uremic Sarcopenia and Mitochondrial Copy Number and Its Clinical Correlates

Association of Uremic Sarcopenia and Mitochondrial Copy Number and Its Clinical Correlates in Taiwanese Hemodialysis Patients

The copy number of the mtDNA and the nDNA is calculated using the threshold cycle number (Ct) and intrapolating from the standard curve. The ratio of the copy number of mtDNA to the copy number of nDNA is measurement of mtDNA content.

ndoxyl sulfate (IS) and para-cresol (p-cresol) belong to the group of protein-bound uremic toxins that are poorly cleared by dialysis and are associated with poor clinical outcomes.the group of protein-bound uremic toxins that are poorly cleared by dialysis and are associated with poor clinical outcomes.

Total 8-iso-PGF2-alpha concentrations in plasma were measured by a specific enzyme immunoassay (EIA) kit

The IL-6 was determined from serum samples and controls using standardized enzymelinked immunosorbent assay (ELISA) methods

The TNF-α was determined from serum samples and controls using standardized enzymelinked immunosorbent assay (ELISA) methods

The LBP was determined from serum samples and controls using standardized enzymelinked immunosorbent assay (ELISA) methods

the fractions of HMA, HNA-1, and HNA-2 to total HSA were measured using HPLC

Tungs’ Taichung Metroharbour Hospital

Roles of Uremic Toxins in Uremic Sacropenia

Association of Uremic Toxins and Sacropenia in Hemodialysis Patients

To evaluate the association of sacropenia defined according to 1. Low muscle mass 2. Low muscle strength 3. Low physical performance and serum levels of some uremic toxins such as indoxyl sulfate, p-cresol and hippuric acid will be measured.

sarcopenia/dichloromethane

Association of Uremic Sarcopenia and Mitochondrial Copy Number and Its Clinical Correlates

Roles of Uremic Toxins in Uremic Sacropenia

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