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9 tulemused
Blockade of retrograde axoplasmic transport induces transganglionic degenerative atrophy of central terminals of primary nociceptive neurons.
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Logi sisse
If applied locally around a peripheral sensory nerve, Formyl-Leurosin, a semi-synthetic diindol alkaloid of Vinca rosea--that, just like other mitotic spindle inhibitors, induces blockade of axoplasmic transport via inhibiting microtubular function--causes transganglionic degenerative atrophy of
Neurofibrillary degeneration induced by Vinca alkaloids: clinical and experimental.
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Anti-spermatogenic effect of Vinca rosea Linn.
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Regressive changes in seminiferous tubules and Leydig cells, increased cholesterol content in testis, and degeneration of all germinal elements other than spermatogonia were observed in the male Swiss albino mice, treated with aqueous extract of V. rosea leaves for 24 days. While the results reflect
Interactions of vinca alkaloid subunits with chiral amido[4]resorcinarenes: a dynamic, kinetic, and spectroscopic study.
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Logi sisse
The stereoselectivity of the reaction between (R)-(-)-2-butylamine and the diastereomeric proton-bound complexes of (+)-catharanthine (C) or (-)-vindoline (V) with some chiral amido[4]resorcinarenes has been investigated in the gas phase by ESI-FT-ICR-MS. The reaction stereoselectivity (0.56 <
Treatment of chronic pain syndromes with iontophoresis of vinca alkaloids to the skin of patients.
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Logi sisse
Repeated iontophoretic administration of the microtubule inhibitors vinblastine or vincristine to the segmentally related dermatomes of patients suffering from postherpetic, trigeminal and other neuralgias permanently alleviates chronic, autochthonous pain. The beneficial effect of this therapy is
Is lithium able to reverse neurological damage induced by vinca alkaloids? (Short communication).
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Lithium (Li) actively antagonises the inhibiting action of vinca alkaloids on human leukocyte chemotaxis; it proved to be related to the activation of microtubular system, possibly mediated by its inhibiting effect on cyclic AMP. Vinca alkaloids induce peripheral neuropathy and muscle damage. The
Axotomy-induced ornithine decarboxylase activity in the mouse dorsal root ganglion is inhibited by the vinca alkaloids.
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Logi sisse
Vinca alkaloids were used to study the role of retrograde axon transport (RT) in activating neuron perikaryal repair response to nerve transection. Mouse lumbar dorsal root ganglia (DRG) (L4-L6) were excised 48 hours after unilateral transection of the sciatic nerve and ornithine decarboxylase (ODC)
Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate.
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We recently developed a new group of folate-conjugated Vinca alkaloids, one of which, EC145, emerged as a candidate for clinical development. Brief treatment of nude mice bearing approximately 100 mm(3) folate receptor-positive human xenografts led to complete response (CR) in 5/5 mice and cures
TrpA1 activation in peripheral sensory neurons underlies the ionic basis of pain hypersensitivity in response to vinca alkaloids.
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Logi sisse
Chemotherapy induced peripheral neuropathy (CIPN), a side effect of many anti-cancer drugs including the vinca alkaloids, is characterized by a severe pain syndrome that compromises treatment in many patients. Currently there are no effective treatments for this pain syndrome except for the
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