Aggrenox-associated acute interstitial nephritis.

Acute interstitial nephritis (AIN) associated with the administration of the combination drug Aggrenox ( acetylsalicylic acid 25 mg and dipyridamole 200 mg) has not been previously reported. This is an 83-year-old man who presented with nausea, vomiting, weakness, and non-oliguric renal failure. He started to have these complaints four days after starting Aggrenox one tablet daily. There were no recent medication changes aside from the addition of Aggrenox. The patient had normal serum creatinine one year prior to this event. The renal biopsy showed acute interstitial nephritis (AIN). The Aggrenox was stopped and the patient received saline intravenously. The serum creatinine rose from 494 mmol/L on admission to a peak of 798 mmol/L on day 5 then decreased gradually to 179 mmol/L over four months. The serologic investigations for common infectious and immune causes of AIN were negative. In conclusion, this patient suffered AIN associated with the administration of Aggrenox and improved with discontinuation of this drug. Further investigation may be needed to evaluate the prevalence of AIN associated with Aggrenox.