[Clinical and laboratory features of cholelithiasis in patients with type 2 diabetes by gender].

OBJECTIVE

Introduction: Today, diabetes is considered a factor that provokes the development of bile duct disease. Cholelithiasis is associated with such risk factors as aging, high body mass index, female sex, genetic predisposition, alcohol abuse, high concentration of triglycerides and cholesterol, low density lipoprotein in blood plasma The aim of the work is to analyze the clinical and laboratory features of the pathology of the gall bladder in patients with type 2 diabetes, depending on the sex.

METHODS

Materials and methods: Complex examination of 126 patients with cholelithiasis and type 2 diabetes mellitus was performed. Diagnosis of chronic cholecystitis was verified on the basis of clinical data, characteristic changes of the wall of the gallbladder according to the data of the echography. In the presence of concretions in the lumen of the gall bladder, bile marijuana was diagnosed. The verification of the diagnosis of diabetes mellitus was based on the determination of carbohydrate balance and glycosylated hemoglobin levels.

RESULTS

Results: Among the examined patients there were 88 women (69,8%) and 38 men (30,2%). The average age of patients was 61,9 ± 0,9 years. The main complaints revealed in patients with combined pathology were: general weakness, daily fluctuations in blood pressure, abdominal distension, irritability, discomfort in the right hypochondrium, bitter taste in the mouth, heartburn, constipation, vomiting with bile. According to ultrasonography, hepatomegaly was noted in 88 (51,8%) patients. An increase in the size of the gall bladder was found in only 27 (15,9%) patients. The individual biochemical parameters of patients with combined pathology are analyzed.

CONCLUSIONS

Conclusions: Established a significant prevalence of female subjects among patients with combined pathology. There were no reliable signs of clinical symptoms and changes in biochemical parameters, depending on sex. A reliable method for diagnosing the changes in the gall bladder in both women and men is ultrasound.