Zhongguo zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban 1999-Apr

[Effect of total flavonoids of Astragalus on nitroxide in ischemia reperfusion injury].

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D Wang

C Wang

Y Tian

مقاله: 11783271

BioSeek: 11783271

کلید واژه ها

phospholipase

خونریزی

ایسکمی

کلروکین

flavonoid

گون

خلاصه

OBJECTIVE

To study the protective effect of total flavonoids of Astragalus (TFA) on ischemia/reperfusion injury.

METHODS

Change of nitrite (NO2-), the terminal product of nitric oxide (NO) metabolism, and the effect of TFA and chloroquine (a phospholipase A2 inhibitor) on it were observed with hemorrhagic shock/reperfusion injury (S/R) rabbit model.

RESULTS

Plasma NO2- content was positively correlated with blood pH and total carbon dioxide content lowering. TFA and chloroquine could block the decrease of NO in certain degree and might have some effect on maintaining acid-base balance of body.

CONCLUSIONS

TFA has protective effect on ischemia/reperfusion injury.