In vivo pharmacokinetics of bakuchiol after oral administration of bakuchiol extraction in rat plasma.

BACKGROUND

Psoralea corylifolia L. (Fabaceae) was a traditional Chinese medicine for the treatment of various skin diseases such as psoriasis, vitiligo and chronic graft-versus-host, and has been proved to show anticancer, cytotoxic, anti-bacterial, cardiac, diaphoretic, diuretic, stimulant, aphrodisiac and tonic effects. Bakuchiol was one of the main active ingredients of this traditional Chinese medicine.

OBJECTIVE

In this paper, pharmacokinetic study was conducted to obtain pharmacokinetic parameters of bakuchiol.

METHODS

Bakuchiol was enriched using resin inform the ethanol extract of Psoralea corylifolia L., HPLC-UV was used to determine the concentration of bakuchiol in rat plasma at different time points after administration. The main pharmacokinetic parameters of bakuchiol in rat were obtained based on the analysis of the plasma sample.

RESULTS

The pharmacokinetics of bakuchiol was fitted with a two-compartment model and it was eliminated relative slowly in rats.

CONCLUSIONS

The HPLC-UV method was successfully applied to study the pharmacokinetics of bakuchiol in rats.