[Isoelectric spectra of blood serum albumin in patients with disturbed thyroid gland function and nephrotic syndrome].

In patients suffering from diffuse toxic goiter, hypothyrosis and nephrotic syndrome changes in dynamics of treatment are found in the albumin molecule by means of the isoelectric focusing in the borate-polyol system and spectropolarimetry. The changes consist in an increased content of the albumin fractions in the range of pH 4.3-4.5 and 5.5-5.7. In patients suffering from toxic goiter conservative therapy rises the content of the fractions in the range of pH 4.3-4.5, whereas under hypothyrosis and nephrotic syndrome the content of the fraction decreases in the range of pH 5.5-5.7. Parallel studies of the dispersion of albumin optic rotation support despiralization of its molecule under all the dispersion of albumin optic rotation support despiralization of its molecule under all types of the pathology. The results obtained may be of diagnostic and prognostic significance.