Phosphatase and actin regulator 1 rs9349379 polymorphism is associated with an elevated susceptibility to coronary artery disease: a meta-analysis.

Some genetic association studies tried to investigate potential associations of phosphatase and actin regulator 1 (PHACTR1) polymorphisms with coronary artery disease (CAD). However, the results of these studies were not consistent. Thus, we performed the present meta-analysis to explore associations between PHACTR1 polymorphisms and CAD in a larger pooled population.Systematic literature research of PubMed, Web of Science, Embase and CNKI was performed to identify eligible studies. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) to estimate strength of associations.

Totally 8 studies were included for analyses (10856 cases and 18801 controls). Pooled analyses suggested that rs9349379 polymorphism was significantly associated with CAD in overall population (dominant model: p=0.004, OR=1.39, 95%CI 1.11-1.73, I² =91%; recessive model: p=0.002, OR=0.63, 95%CI 0.48-0.84, I² =85%; over-dominant model: p=0.03, OR=0.89, 95%CI 0.80-0.99, I² =59%; allele model: p=0.0002, OR=1.30, 95%CI 1.13-1.49, I² =89%), and this significant finding was further confirmed in both Asians and Caucasians. However, no any positive findings were observed for rs2026458 polymorphism in pooled analyses.

Our meta-analysis suggested that rs9349379 polymorphism might affect individual susceptibility to CAD in both Caucasians and Asians. Future investigations need to explore the underlying molecular mechanisms of our positive findings.