[Treatment of malignant pleural effusion using vindesine and cisplatine intrapleurally injection (observation of 60 cases)].

OBJECTIVE

To evaluate the efficacy of treating malignant pleural effusion with cisplatine and vindesine by injection through thoracic tube intubation.

METHODS

60 cases with malignant pleural effusion, after drainage, vindesine 4 mg, cisplatine 40 mg/m(2) were injectred into pleural cavity in therapy group (T), and only cisplatine 40 mg/m(2) in control group (C). the tretment was repeated after a week, then evaluate the efficacy, survival rate, toxicities and quality of life.

RESULTS

The response rate was 81% in T group and 50% in C group. There was statistical difference in two groups (P < 0.05). The Karnofsky score is higher in T group than in C group. The half-year, one-year, one and half-year, two-year survival rates were 97%, 59%, 44%, 6% in T group and 71%, 50%, 14%, 4% in C group. Grade I leukopenia is higher in T group than in C group.

CONCLUSIONS

The treatment to use Vindesine and cisplatine through thoracic tube is regarded as effective, slight side-effect and well tolerated method for malignant pleural effusion.