Comparative Study on Hemoglobin A1c, Glycated Albumin and Glycosylated Serum Protein in Aplastic Anemia Patients with Type 2 Diabetes Mellitus.

To differentiate the value of Hemoglobin A1c(HbA1c), Glycated Albumin(GA), and Glycosylated Serum Protein(GSP) in monitoring blood glucose of patients with aplastic anemia.42 patients with aplastic anemia (AA) and 30 patients with AA and type 2 diabetes mellitus (T2DM) were enrolled in the study, in comparison with 114 healthy subjects and 88 subjects with T2DM. HbA1c, GA, GSP, Fasting Plasma Glucose(FPG), hemoglobin(Hb), and albumin(ALB) were measured, and group comparison and correlation analysis were carried out. Compared with the non-diabetes patients while ALB were40g/L had higher HbA1c level, with no difference in GA, GSP and FPG levels. There was a positive correlation between HbA1c and GA in healthy group (ALB≥40g / L), AA patients (ALB 30-40g / L and ≥40g / L), T2DM patients (ALB 30-40g / L and ≥40g / L) and AA+T2DM patients(alb 30-40g / L and ≥40g / L) but not in those with ALB.The HbA1c results were affected by moderate to severe anemia, but not mild anemia. HbA1c is not recommended to detect blood glucose levels in AA patients (Hb<90g/L) or AA patients (Alb <30g/L). FPG and GSP are not suitable for AA patients.