Four patients with infarction in key areas of the Papez circuit, with anterograde amnesia as the main manifestation

The Papez circuit is an important brain structure that is closely associated with learning and memory. In this report, we present four patients with anterograde amnesia as the main manifestation induced by Papez circuit infarction. In addition, we review the distribution of the responsible arteries in key and rare regions to investigate the pathogenesis of these infarctions.

Keywords: Papez circuit; anterograde amnesia; cerebral ischemia; hippocampus; learning and memory; medial limbic circuit; memory decline.