صفحه 1 از جانب 23 نتایج
BACKGROUND OF THE INVENTION
Malignant hyperthermia is an inherited skeletal muscle disorder of humans and pigs. The disease is characterized by an accelerated muscle metabolism, contracture development, and rapidly rising temperature in response to certain halogenated anesthetics. Once initiated, a
FIELD OF THE INVENTION
This invention relates to the animal disease malignant hyperthermia (MH) and to the cloning and characterization of a gene associated with (MH), and to the development of methods for detecting individuals susceptible to MH.
BACKGROUND OF THE INVENTION
Although malignant
CROSS-REFERENCE TO RELATED APPLICATION
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
BACKGROUND OF THE INVENTION
Malignant hyperthermia (MH), a pharmacogenetic disorder of skeletal muscle elicited by exposure to volatile anesthetics and depolarizing muscle relaxants, is well
The present invention concerns the use of an androstane derivative of the formula ##STR2## in which X.sup.- represents a pharmaceutically acceptable anion, or its pharmaceutically acceptable salts for the preparation of a medicament with prophylactic properties against malignant hyperthermia. Said
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to systems, methods and apparatus for the removal of volatile anesthetics from an anesthesia or ventilation system. In more particular, the present invention relates to a two-part or dual filter apparatus for removal
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to systems, methods and apparatus for the removal of volatile anesthetics from an anesthesia or ventilation system. In more particular, the present invention relates to a two-part or dual filter apparatus for removal
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a new method of diagnosing malignant hyperthermia (MH) using a few milliliters of blood.
2. Background Art
MH is a serious complication of anesthesia with a high risk of death. The symptom (muscle rigidity and/or
FIELD OF THE INVENTION
This invention relates to the animal disease malignant hyperthermia (MH), to the cloning and characterization of a gene associated with MH in swine, and to the development of DNA and antibody-based methods for detecting individual pigs susceptible to MH.
BACKGROUND OF THE
FIELD OF THE INVENTION
This invention relates to the animal disease malignant hyperthermia (MH), to the cloning and characterization of a gene associated with MH in swine, and to the development of DNA and antibody-based methods for detecting individual pigs susceptible to MH.
BACKGROUND OF THE
TECHNICAL FIELD
This invention is concerned with a method for the treatment of malignant hyperthermia. More particularly, it is concerned with the use of azumolene for the treatment of malignant hyperthermia.
BACKGROUND OF THE INVENTION
The incidence, etiology, clinical manifestations, and
FIELD OF THE INVENTION
A novel uncoupling protein, which we have designated UCP-4, that is expressed in various tissues, including brain, heart, pancreas, and muscle tissue, and nucleic acid molecules which encode said novel protein, are described. Methods of screening for compounds that regulate
FIELD OF THE INVENTION
The present invention relates generally to a co-solvent system for formulation and production of a pharmaceutical agent with increased solubility. The present invention also provides for methods of using tert-butyl alcohol (TBA) co-solvent systems in the formulation and
BACKGROUND OF THE INVENTION
Field of the Invention
This invention relates to the prophylactic and therapeutic use in mammals, particularly man, of dantrolene and its salts, relatives and analogs. Low volume safe for injection formulations of dantrolene provide improved prevention and treatment for
BACKGROUND OF THE INVENTION
Field of the Invention
This invention relates to the prophylactic and therapeutic use in mammals, particularly man, of dantrolene and its salts, relatives and analogs. Low volume safe for injection formulations of dantrolene provide improved prevention and treatment for
BACKGROUND OF THE INVENTION
Field of the Invention
This invention relates to the prophylactic and therapeutic use in mammals, particularly man, of dantrolene and its salts, relatives and analogs. Low volume safe for injection formulations of dantrolene provide improved prevention and treatment for