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neuroma/پتاسیم

پیوند در کلیپ بورد ذخیره می شود
صفحه 1 از جانب 16 نتایج

Abnormal distributions of potassium channels in human neuromas.

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Twenty-seven human traumatic neuromas were examined immunocytochemically using highly specific antibodies directed against the voltage-gated delayed-rectifier potassium channel, Kv1.1. Normal sural nerves from six of the above-noted patients served as control specimens. Additionally, nine of the

Effects of potassium channel-blocking agents on spontaneous discharges from neuromas in rats.

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Thirty-five Sprague-Dawley rats with saphenous neuromas underwent acute microfilament recording in the proximal nerve. The effect of the potassium channel-blocking agents, tetraethylammonium bromide (TEA) and 4-aminopyridine, on spontaneous activity in A fibers terminating in the neuroma was

Potassium channels moderate ectopic excitability of nerve-end neuromas in rats.

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The potassium conductance (gK) blockers tetraethylammonium (TEA) and 4-aminopyridine (4-AP) strongly excited experimental neuromas that had spontaneous discharge, but had minimal effects on acutely cut nerves and on old, quiescent neuromas. Resting gK apparently moderates hyperexcitability in active

Use of the KTP-532 laser in acoustic neuroma surgery.

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The potassium titanyl phosphate (KTP-532) laser has been applied to otologic surgery with a proven record of both safety and efficacy. The aim of this study was to demonstrate the use, safety, and advantages of laser dissection in the surgical treatment of acoustic neuromas. The authors' experience

Specific cellular immunity in acoustic neuroma patients.

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An indirect leukocyte migration agarose technique to detect cell-mediated immunity was modified to obtain a specific assay for release of human leukocyte migration inhibitory factor. Acoustic neuroma patients exhibited a significant cellular immune response against acoustic neuroma extract (P less

Has the amount of spontaneous electrical activity in experimental neuromas been overestimated?

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Previous studies of experimental neuromas have indicated that some axons terminating in the neuroma exhibit both spontaneous and mechanosensitive discharges. Since these spontaneous discharges appear to occur in potentially nociceptive axons (A delta and C fibers), it has been speculated that this

Spontaneous activity in afferent and efferent fibers after chronic axotomy: response to potassium channel blockade.

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Distally propagating spontaneous impulses in acutely and chronically cut rat saphenous nerve were examined to determine (1) the origin(s) of the activity, (2) the fiber types involved, and (3) whether the activity was affected by potassium channel blockade. Under deep pentobarbital anesthesia, six

Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury.

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Neuropathic pain following peripheral nerve injury is associated with hyperexcitability in damaged myelinated sensory axons, which begins to normalise over time. We investigated the composition and distribution of shaker-type-potassium channels (Kv1 channels) within the nodal complex of myelinated

Cold sensitivity in axotomized fibers of experimental neuromas in mice.

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Cold allodynia is a common complaint in patients with peripheral neuropathies. However, cold sensitivity of the different types of sensory afferents present in injured nerves is poorly known. We recorded activity evoked by cold in intact sensory fibers of the skin-saphenous nerve preparation and in

Anti-convulsants and anti-depressants.

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Damage to a nerve should only lead to sensory loss. While this is common, the incidence of spontaneous pain, allodynia and hyperalgesia indicate marked changes in the nervous system that are possible compensations for the loss of normal function that arises from the sensory loss. Neuropathic pain

Mechanical sensitivity of regenerating myelinated skin and muscle afferents in the cat.

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These experiments describe the responses of myelinated skin and muscle afferent nerve fibres at a neuroma to stretch, local pressure and vibration in the anaesthetised cat. The sural nerve and the nerve supplying the medial gastrocnemius were studied. Neuroma formation was encouraged by placing the

Tc-99m MIBI brain SPECT of cerebellopontine angle tumors.

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To prospectively evaluate the imaging feasibility of Tc-99m sestamibi brain SPECT of cerebellopontine angle (CPA) tumors, seven patients with CPA lesions seen on CT or MRI and five normal control subjects underwent brain SPECT using a triple-headed camera. Five of these patients had acoustic

Adrenergic innervation of the human endolymphatic sac.

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Adrenergic innervation of the human endolymphatic sac (ES) has not been verified previously. To investigate this question a sensitive histofluorescence method for visualization of catecholamines and serotonin, using a solution composed of sucrose-potassium phosphate-glyoxylic acid (SPG) in cryostat

Pain responses to perineuromal injection of normal saline, gallamine, and lidocaine in humans.

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Rat neurons have shown an increase of spontaneously active fibers to systemically administered potassium channel blocking agents such as tetraethylammonium chloride (TEA) and gallamine. Neuroma formation and spontaneous activity have been associated with autotomy in rats and pain in humans. To

Afterdischarge and interactions among fibers in damaged peripheral nerve in the rat.

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Sensory fibers trapped in nerve-end neuromas become abnormally excitable, and produce an ectopic discharge which is believed to contribute to paresthesias and pain associated with chronic nerve injury in man. Here we report that stimulation of injured nerves can alter this discharge, directly by
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