Fungal Infection

Onychomycosis

Fungus, Nail

amphotericin B in 30% DMSO was given to patients in active comparators group for continuous 12 weeks.

amphotericin B in 30% DMSO

30% DMSO was given to patients in placebo comparators group for continuous 12 weeks.

30% DMSO

Department of Dermatology Siriraj Hospital

Topical Amphotericin B in 30% Dimethylsulphoxide in Treating of Non-dermatophytes Onychomycosis

Comparison of Effectiveness of Topical Amphotericin B in 30% Dimethylsulphoxide and 30% Dimethylsulphoxide in Treating of Non-dermatophytes Onychomycosis: Randomized Double Blind Controlled Trial Pilot Study

Effectiveness was evaluated by patients who had negative on mycological laboratory (mycological cure) as percentage.

Median time to mycological cure were defined as time (days, months or years) that had negative on mycological laboratory

Clinical cure was defined as the patients had complete clinical improvement or having <10% nail involvement.

Median time to clinical cure were defined as time (days, months or years) that had clinical improvement of the affected nails.

Side effects was assessed by the percentage of patients developed any side effect such as erythema, burning sensation, pain.

Mahidol University

Randomized double blind controlled trial pilot study

Double blind controlled trial between participants, drug preparing team, doctors, investigators, and outcome assessors.

Those in the control group do not obtain a dermatology evaluation and will be assessed and treated by their primary care provider. We will perform a chart review two weeks after presentation to assess for admission versus discharge home from clinic and outcome.

Patients randomized to the treatment group will obtain a dermatology evaluation at the primary care physician's office and will be sent to the Emergency Department (ED) or discharged home with outpatient dermatology follow-up in 2-3 days to assess their condition. Patients who are evaluated by a dermatologist and require hospitalization will have their transition to the ED managed by the dermatologist. Patients who are admitted after the initial outpatient discharge or at the follow-up visit will be considered treatment failures. A medical record review will be performed for patients in the treatment group two weeks after initial evaluation at the internal medicine clinic.

Cellulitis

A dermatology consultation will be conducted on patients randomized to this group.

Dermatology Consultation

Massachusetts General Hospital

A Study Assessing the Impact of Dermatology Consultation in Patients Presenting With Possible Cellulitis

A Randomized-controlled Study to Assess the Impact of Dermatology Consultations on Reducing Admissions for Patients Presenting to Internal Medicine Clinics for Possible Cellulitis

We will be recording whether an antibiotic was prescribed, which antibiotic was used, the duration of treatment, the dosage of antibiotic, the cost of the antibiotic, and any adverse events related to antibiotic usage.

Daniela Kroshinsky

Principal Investigator

Those who are in the control group will follow internal medicine hospitalist recommendations alone which will include when and what type of post-discharge follow-up appointments the patient will have. We would like to emphasize that as part of the standard of care, patients in the control arm may still receive a dermatology consult if it is deemed necessary and/or requested. We will not prevent patients or the patient's team of caregivers from requesting a dermatology consultation during the course of hospitalization. A follow-up phone call will be performed two weeks after discharge for patients in the control group in order to confirm the patient's outcome. There will also be a medical record review one month after the patient's initial discharge from the hospital to assess for readmission

The patients randomized to the treatment group will obtain a dermatology evaluation within 24 hours of being admitted to MGH for their cellulitis. The skin and lymph node exam performed by the dermatologist on patients in the treatment group will be documented in the LMR for the subjects' medical records. Patients who are readmitted for cellulitis within one month of being discharged from the hospital will be considered treatment failures. Patients in the treatment group will have a follow-up visit in dermatology clinic within two weeks after being discharged. There will also be a medical record review performed one month after the patient's initial discharge from the hospital to assess for readmission.

Dermatology consult

Study Assessing Impact of Dermatology Consultation for Patients Admitted With Cellulitis

A Randomized Controlled Study to Assess the Impact of Dermatology Consultations on the Hospital Course of Patients Admitted for Cellulitis

We will be measuring the difference between antibiotic usage in patients in the control group as compared with the treatment group

We will be comparing the length of admission between the control group and the treatment group to assess whether a dermatology consult has any impact on the length of a patient's hospital stay.

We will be measuring the readmission rate among patients in both groups in order to discover whether a dermatology consult has an impact on readmission rates among patients with cellultis.

onychomycosis/fever

Topical Amphotericin B in 30% Dimethylsulphoxide in Treating of Non-dermatophytes Onychomycosis

A Study Assessing the Impact of Dermatology Consultation in Patients Presenting With Possible Cellulitis

Study Assessing Impact of Dermatology Consultation for Patients Admitted With Cellulitis

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