All subjects will be taking a glutathione supplement.Glutathione is a naturally occuring antioxidant and a nonessential amino acid.

All subjects were assigned the intervention. The intervention was a three-month trial of twice daily, oral, 1,000 mg glutathione supplements (Glutathione 500 Ultrathione, The Glutathione Corporation, Elmsford, New York; 500 mg. capsule with 250 mg. ascorbic acid).

Study Group

Gender

Race (NIH/OMB)

Region of Enrollment

Assesses the ability to carry out activities that require physical actions, ranging from self-care (activities of daily living) to more complex activities that require a combination of skills, often within a social context. Scores are standardized T-scores with mean of 50 and standard deviation of 10; higher scores indicate better physical function.

PROMIS Physical Functioning

Sleep efficiency is defined as the ratio of time sleeping and time in bed. Using a sleep diary, participants recorded bedtime the night before, amount of time it took to fall asleep, number and total duration of awakenings, time of final awakening, and time of rising. Efficiency ranges from 0 to 100; higher values indicate higher sleep efficiency or more time sleeping when in bed.

Subjective sleep efficiency

Assesses fatigue from mild subjective feelings to an overwhelming, debilitating, and sustained sense of exhaustion that is likely to decrease one's ability to carry out daily activities, including the ability to work effectively and to function at one's usual level in family or social roles. Fatigue is divided conceptually into the experience of fatigue (e.g., frequency, duration, and intensity), and the impact of fatigue upon physical, mental and social activities.Scores are standardized T-scores with mean of 50 and standard deviation of 10; higher scores indicate greater fatigue.

PROMIS Fatigue

Refers to cumulative steps per day (24 hours period). 10,000 or more steps per day is considered optimal.

Physical activity, number of steps daily

Ability to carry out activities that require physical actions, ranging from self-care (activities of daily living) to more complex activities that require a combination of skills, often within a social context. Scores are standardized T-scores with mean of 50 and standard deviation of 10; higher scores indicate better physical function.

PROMIS (Patient Reported Outcomes Measurement Information System) Physical Functioning

The ratio of time asleep over time in bed gathered from sleep diaries completed at bedtime and at awakening. Scores range from 0 to 100%, higher values indicate better sleep efficiency or more time sleeping in bed.

All subjects took a three month trials of 1,000 mg of glutathione supplement

Sleep Efficiency

Count of steps per day using activity monitor worn on upper arm.

Steps Per Day

Assesses fatigue from mild subjective feelings to an overwhelming, debilitating, and sustained sense of exhaustion that is likely to decrease one's ability to carry out daily activities, including the ability to work effectively and to function at one's usual level in family or social roles. Fatigue is divided conceptually into the experience of fatigue (e.g., frequency, duration, and intensity), and the impact of fatigue upon physical, mental and social activities. Scores are on a T-metric with mean of 50 and standard deviation of 10; higher scores indicate greater fatigue.

PROMIS (Patient Reported Outcomes Measurement Information System) Fatigue

Overall Study

Claire Z. Kalpakjian

Post-polio Syndrome

Physical Activity

Depression

Pain

Sleep Disorders

glutathione is a dietary supplement and an antioxidant. Subjects will take 1000 mg per day for three month. Each capsule contains 500 mg glutathione.

poliomyelitis/گلوتاتیون

Glutathione and Health With Post-Polio Syndrome

کاملترین پایگاه داده گیاهان دارویی با پشتیبانی علمی