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Reduced airway inflammation and remodeling in parallel with mucin 5AC protein expression decreased by s-carboxymethylcysteine, a mucoregulant, in the airways of rats exposed to sulfur dioxide.

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BACKGROUND Human obstructive airway diseases are histopathologically characterized by inflammatory cell infiltration, goblet cell hyperplasia, and mucus hypersecretion in airways. We prepared a rat model of airway injury by exposure of sulfur dioxide (SO2) and then evaluated the effects of

The effect of erdosteine and its active metabolite on reactive oxygen species production by inflammatory cells.

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OBJECTIVE We examined the effect of erdosteine (KW-9144), an expectorant, and related compounds on inflammatory cell-derived reactive oxygen species which are involved in airway inflammation. METHODS Neutrophils were isolated from peritoneal lavages of casein-injected rats and from peripheral blood

Nebulization of S-carboxymethylcysteine does not adversely affect the mucociliary system in the paranasal sinus and trachea of the healthy rabbit.

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Chronic sinusitis is a persistent inflammatory impairment of the paranasal sinus. Disturbance of the mucociliary function in the paranasal sinus is the most common finding in chronic sinusitis. S-carboxymethylcysteine (S-CMC) has been shown to directly enhance the ciliary activity of the chronic

S-carboxymethylcysteine inhibits adherence of Streptococcus pneumoniae to human alveolar epithelial cells.

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Streptococcus pneumoniae is a major pathogen of respiratory infections that utilizes platelet-activating factor receptor (PAFR) for firm adherence to host cells. The mucolytic agent S-carboxymethylcysteine (S-CMC) has been shown to exert inhibitory effects against infection by several respiratory

Effect of fudosteine, a cysteine derivative, on blood flow of tracheal microvasculature increased by airway inflammation.

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We examined the effect of fudosteine, a cysteine derivative, on blood flow of tracheal microvasculature increased by airway inflammation. Airway inflammation was elicited by sulfur dioxide (SO(2)) exposure for 2 weeks in rabbits. Each drug (500 mg/kg, p.o.) or 0.5% carboxymethylcellulose-Na (control

[Effect of S-carboxymethylcysteine on blood levels of amoxycillin and its diffusion through lung parenchyma and pleural exudate in the rat].

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The fixed combination (10 : 3) of amoxycillin and S-carboxymethylcysteine, which is indicated in the therapy of the respiratory tract infections, was given to rats by oral route to determine the blood levels and the concentrations in the pulmonary parenchyma and pleural exudate. In comparison with

Erdosteine enhances mucociliary clearance in rats with and without airway inflammation.

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Erdosteine is a new homocysteine-derived expectorant and has been reported to have many mucolytic effects. In this report, we studied the activities of erdosteine on mucociliary clearance in normal and airway-inflammation-induced rats. In normal rats, erdosteine at doses of 100-600 mg/kg

S-carboxymethylcysteine normalises airway responsiveness in sensitised and challenged mice.

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S-carboxymethylcysteine (S-CMC) has been used as a mucoregulator in respiratory diseases. However, the mechanism of action of S-CMC on allergic airway inflammation has not yet been defined. In the present study, BALB/c mice were initially sensitised and challenged to ovalbumin (OVA) and, weeks

The role for S-carboxymethylcysteine (carbocisteine) in the management of chronic obstructive pulmonary disease.

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Prescription of mucoactive drugs for chronic obstructive pulmonary disease (COPD) is increasing. This development in clinical practice arises, at least in part, from a growing understanding of the important role that exacerbation frequency, systemic inflammation and oxidative stress play in the

Effects of SS320A, a new cysteine derivative, on the change in the number of goblet cells induced by bacterial endotoxin in rat tracheal epithelium.

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We examined the effects of SS320A, a new cysteine derivative, on the change in the number of goblet cells induced by bacterial endotoxin in rat tracheal epithelium. Four types of goblet cell were characterized in tracheal epithelium according to their size and staining affinity with Alcian blue

[Pharmacology of mucociliary transport].

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Muco-ciliary transport is only effective because of the coordination of the ciliary beats (metachronous) and the harmony between mucus and cilia. The tip of the cilia is in contact with a jellyform layer of mucus propelled to the oropharynx. This jellyform layer has a complex rheological behaviour:

Drug-mucus actions and interactions.

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Although it has generally been accepted that the main structural component of mucus secretions is the high molecular weight glycoprotein it has now been established that other macromolecules are co-secreted. For example, lysozyme, lactoferrin and albumin are known to be secreted by the serous cells

Reversibility of reduced mucociliary clearance in chronic sinusitis.

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Nasal mucociliary clearance was measured before and after treatment in patients with chronic sinusitis. Nasal mucociliary transit time before the study was greater than 36 min in 8 out of 14 patients who were treated with S-carboxymethylcysteine, and in 9 out of 22 patients who were treated by

The effect and mechanism of action of carbocysteine on airway bacterial load in rats chronically exposed to cigarette smoke.

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OBJECTIVE Carbocysteine (S-carboxymethylcysteine) is a mucoactive drug with in vitro free radical scavenging and anti-inflammatory properties. Several clinical trials have indicated that carbocysteine reduces exacerbation rates in COPD. In the present study, the effect of carbocysteine on the airway

[Recurrent secretory otitis media and adenoidism. A retrospective study of the results observed with the medical and surgical therapy of 1250 children].

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A retrospective study, between 1982 and 1993, on 1250 children with otitis media with effusion and hypertrophic adenoids was carried out. 1150 children were selected from those who had been administered S-carboxymethylcysteine-lysine for three months period, and antihistaminics, decongestants and

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Herbal & Natural Medicine

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