10 نتایج
BACKGROUND OF THE INVENTION
Mammalian Endogenous Cannabinoid System
The various elements of the mammalian endogenous cannabinoid system (ECS) constitute a variety of pharmacological targets for the broad group of compounds generally termed as cannabinoids. Included among these elements are two types
BACKGROUND OF THE INVENTION
Mammalian Endogenous Cannabinoid System
The various elements of the mammalian endogenous cannabinoid system (ECS) constitute a variety of pharmacological targets for the broad group of compounds generally termed as cannabinoids. Included among these elements are two types
BACKGROUND OF THE INVENTION
Mammalian Endogenous Cannabinoid System
The various elements of the mammalian endogenous cannabinoid system (ECS) constitute a variety of pharmacological targets for the broad group of compounds generally termed as cannabinoids. Included among these elements are two types
FIELD OF THE INVENTION
The present invention relates to bisarylimidazolyl derivatives and pharmaceutical compositions comprising said derivatives which inhibit fatty acid amide hydrolase and are useful for the treatment of conditions affected by inhibiting fatty acid amide
FIELD OF THE INVENTION
The present invention relates to compounds and their uses, and in particular to compounds and their therapeutic use in the treatment or prevention of conditions having an association with substrates, such as the neurotransmitter anandamide, which are broken down by the fatty
FIELD OF THE INVENTION
The present invention relates to compounds and their uses, and in particular to compounds and their therapeutic use in the treatment or prevention of conditions having an association with substrates, such as the neurotransmitter anandamide, which are broken down by the fatty
The present disclosure relates to the fields of pharmaceutical and organic chemistry, and provides 4,5-dihydro-(1H)-pyrazole (pyrazoline) derivatives as cannabinoid CB.sub.1 receptor modulators, intermediates for synthesizing these compounds, formulations comprising these compounds, methods for
BACKGROUND
Agriculture is the cultivation and breeding of animals, plants and fungi for food, fiber, biofuel, medicinal plants and others. The dominant agricultural methodology in modern times, often referred to as industrial agriculture, is typically based on large-scale monoculture farming and
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is the U.S. National Phase of International Patent Application No. PCT/NL2014/050746, filed Oct. 29, 2014, published on May 7, 2015 as WO 2015/065180 A1, which claims priority to European Patent Application No. 13190577.0, filed Oct. 29, 2013.
BACKGROUND OF THE INVENTION
Classical cannabinoids such as the marijuana derived cannabinoid .DELTA..sup.9-tetrahydrocannabinol, (.DELTA..sup.9-THC) produce their pharmacological effects through interaction with specific cannabinoid receptors in the body. So far, two cannabinoid receptors have been