Cohort 1 will consist of the first 20 participants recruited into the study for H1 Hip Resurfacing Arthroplasty. These patients will receive additional CT scans preoperatively and then post-operatively at these time points: immediately postoperatively (2days), at 6 weeks, 3 months, 6 months, 1 year and 2 years. They will have metal-ion measurements for safety analysis. Blood samples will be taken preoperatively and postoperatively at 3 months, 6 months, 1 year and 2 years.
A safety analysis of Cohort 1 will be performed at the 6 week, 3 month and 6 month post-operative stage by independent assessors. Yearly clinical evaluations will be performed until 10 years, and radiographs at 3,5,10 years. If the investigation supports the safety of the implant, the study will proceed with recruitment into Cohort 2.

Cohort 2 will consist of the remaining target size population of 230 patients for H1 Hip Resurfacing Arthroplasty. They will undergo the same intervention as previously described for Cohort 1, but will not undergo metal-ion testing and reduced frequency CT-scans.

5 samples of 2ml of Blood stored in EDTA tubes will be taken and analysed for metal ion levels

Hip Osteoarthritis

Hip Necrosis

Hip Dysplasia

A non-porous non-cemented ceramic-on-ceramic hip resurfacing arthroplasty device

H1 Hip Resurfacing Arthroplasty

Charing Cross Hospital

Kind Edward VII's Hospital

A Prospective, Non-randomized, Consecutive Series, Multicentre, Observational Study to Evaluate the Clinical Outcome of ceramic-on- Ceramic Hip Resurfacing Arthroplasty Using the Ceramic, Non-porous, Non-cemented H1 Hip Resurfacing Arthroplasty

Hip Specific Patient Reported Outcome Measure (PROM)

Generic Patient Reported Outcome Measure (PROM)

Evaluation of AP and Lateral Hip Radiographs, measured in degrees

CT to evaluate component migration and bone ingrowth (Safety study - Cohort 1 - 20 patients)

Concentration of metal ions in patient's blood (Safety study - Cohort 1 - 20 patients)

Embody Orthopaedic Limited

Imperial College London

ST-Elevation Myocardial Infarction

State University of Campinas

Brasilia Heart Study

Brasilia Heart Study of Outcome Markers in ST-elevation Myocardial Infarction

Sudden cardiac death (unrelated to trauma, unexpected, and occurring in less than six hours after onset of symptoms), fatal MI (any death preceded by MI) or non-fatal MI.

Assessment of endothelial function on brachial artery. The flow-mediated dilation was measured.

Left Ventricular (LV) Remodeling as indicated by LV end-diastolic diameter (LVEDD), LV end-systolic diameter (LVESD), LV septum diastolic thickness (SD) and posterior wall diastolic thickness (PD).

vanadium/نکروز

H1 Hip Resurfacing Arthroplasty

Brasilia Heart Study

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