wallerian degeneration/خیز

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Inhibitory effects of thalidomide on cellular proliferation, endoneurial edema and myelin phagocytosis during early wallerian degeneration.

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In addition to the well-known teratogenic effect of thalidomide, previous studies have revealed mild immunosuppressive properties and, more recently, an anti-angiogenic activity. To find out more about the specificity of these effects we studied the influence of orally administered thalidomide on

Perineurial permeability and endoneurial edema during Wallerian degeneration of the frog peripheral nerve.

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Perineurial permeabilities to [3H]sucrose and [14C]dextran (MW = 70,000), and water content, conduction velocity (CV) and maximum amplitude (MAP) of the compound action potential, were determined in Wallerian degenerated nerves (sciatic or tibial) of the frog and compared with values in the

Prolonged T1 values of the crushed nerve are not exclusively attributable to Wallerian degeneration or endoneurial edema.

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Axonotmesis of the left sciatic nerve was performed on adult male Wistar rats. T1 values of the crushed nerve samples were determined with proton magnetic resonance spectroscopy. Denervation changes of the dependent hind plantar flexor muscles were assessed with proton magnetic resonance imaging of

The role of focal nerve ischemia and Wallerian degeneration in peripheral nerve injury producing hyperesthesia.

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BACKGROUND A new model of pain associated with an experimental peripheral mononeuropathy has stimulated interest in mechanisms of pain and their structural correlates in peripheral nerve, the site of the experimental lesion. METHODS The pathology of the neuropathy was studied and the results

Diffusion-weighted imaging of acute corticospinal tract injury preceding Wallerian degeneration in the maturing human brain.

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OBJECTIVE Wallerian degeneration, the secondary degeneration of axons from cortical and subcortical injury, is associated with poor neurologic outcome. Since diffusion-weighted (DW) imaging is sensitive to early changes of cytotoxic edema, DW imaging may depict the acute injury to descending white

The rate of Wallerian degeneration in the absence of immunoglobulins. A study in chick and mouse peripheral nerve.

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Sciatic nerves undergoing Wallerian degeneration are subject to massive invasion by monocytes bearing Fc receptors. The present experiments were done to explore the potential role of the Fc receptors. The effect of suppressed immunoglobulin levels on the rate of Wallerian degeneration was studied in

Histological Assessment of Wallerian Degeneration of the Rat Tibial Nerve Following Crush and Transection Injuries

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Background: Wallerian degeneration (WD) following peripheral nerve injury (PNI) is an area of growing focus for pharmacological developments. Clinically, WD presents challenges in achieving full functional recovery following PNI, as

Imaging of cauda equina edema in lumbar canal stenosis by using gadolinium-enhanced MR imaging: experimental constriction injury.

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OBJECTIVE It has been reported that disturbance of blood flow arising from circumferential compression of the cauda equina by surrounding tissue plays a major role in the appearance of neurogenic intermittent claudication (NIC) associated with lumbar spinal canal stenosis (LSCS). We created a model

The acute phase of Wallerian degeneration: longitudinal diffusion tensor imaging of the fornix following temporal lobe surgery.

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Numerous animal studies have shown the applicability of diffusion tensor imaging (DTI) to track Wallerian degeneration that occurs after injury to the neural fiber. Non-invasive biomarkers that may differentiate the early axonal breakdown and later myelin degradation have been attributed to either

Wallerian degeneration and inflammation in rat peripheral nerve detected by in vivo MR imaging.

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To investigate the role of MR imaging in wallerian degeneration, a series of animal models of increasingly complex peripheral nerve injury were studied by in vivo MR. Proximal tibial nerves in brown Norway rats were either crushed, transected (neurotomy), or transected and grafted with Lewis rat

Endoneurial fluid pressure in wallerian degeneration.

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Endoneurial fluid pressure (EFP) was recorded by an active, servo-null pressure system after a glass micropipette was inserted into rat sciatic nerve undergoing wallerian degeneration. The lesions were produced by crushing the left sciatic nerve of the anesthetized animal at its point of entry into

Perineurial permeability to sodium during Wallerian degeneration in rat sciatic nerve.

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In rat sciatic nerves, the effect of Wallerian degeneration on the rate of transperineurial passage of sodium between the endoneurium and the epineurial extracellular space was investigated. In nerves transected and ligated at the sciatic notch, an in situ technique was used to measure the

Spatial distribution of nerve injury after occlusion of individual major vessels in rat sciatic nerves.

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In an attempt to better understand the spatial distribution of ischemic injury secondary to occlusion of major arteries, we measured nerve blood flow (NBF) and studied morphologic changes at various levels distal to the ligature site. Arterial ligation of the femoral, internal iliac, or superior

Pathology of lumbar nerve root compression. Part 1: Intraradicular inflammatory changes induced by mechanical compression.

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METHODS This study is to investigate the intraradicular inflammation induced by mechanical compression using in vivo model. OBJECTIVE The relationship between the intraradicular edema and nerve fiber degeneration induced by mechanical compression was determined in the nerve root. BACKGROUND Recently

Synapse involvement of the dorsal horn in experimental lumbar nerve root compression: a light and electron microscopic study.

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METHODS This study was aimed at investigating changes in the dorsal horn of the lumbar cord induced by mechanical compression using an in vivo model. OBJECTIVE To determine the effect of axonal flow disturbance in the dorsal horns induced by nerve root compression. BACKGROUND Few studies have looked

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Herbal & Natural Medicine

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