The Evaluation of Chenopodium Formosanum and Fagopyrum Esculentum Extract on Anti-aging Effect

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KLIININEN TUTKIMUS: NCT04237818

BioSeek: nct04237818

Avainsanat

savikat

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tattari

ikääntymistä vastaan

Abstrakti

To assess Chenopodium Formosanum and Fagopyrum Esculentum Extract on skin anti-aging

Päivämäärät

Viimeksi vahvistettu:	12/31/2019
Ensimmäinen lähetys:	01/18/2020
Arvioitu ilmoittautuminen lähetetty:	01/21/2020
Ensimmäinen lähetetty:	01/22/2020
Viimeisin päivitys lähetetty:	03/05/2020
Viimeisin päivitys lähetetty:	03/08/2020
Todellinen opintojen alkamispäivä:	01/31/2020
Arvioitu ensisijainen valmistumispäivä:	09/29/2020
Arvioitu tutkimuksen valmistumispäivä:	12/30/2020

Ehto tai tauti

Skin Condition

Interventio / hoito

Dietary Supplement: Placebo drink

Dietary Supplement: Chenopodium Formosanum and Fagopyrum Esculentum Extract drink

Vaihe

Varren ryhmät

Varsi	Interventio / hoito
Placebo Comparator: Placebo drink	Dietary Supplement: Placebo drink consume 2 bottle (30 mL) per day for 56 days
Experimental: Chenopodium Formosanum and Fagopyrum Esculentum Extract drink	Dietary Supplement: Chenopodium Formosanum and Fagopyrum Esculentum Extract drink consume 2 bottle (30 mL) per day for 56 days

Kelpoisuusehdot

Tutkimukseen soveltuvat iät	20 Years Vastaanottaja 20 Years
Sukupuolet, jotka ovat kelpoisia tutkimukseen	All
Hyväksyy terveelliset vapaaehtoiset	Joo
Kriteeri	Inclusion Criteria: - Healthy adults aged between 20-65 years old - Subjects must read and sign the informed consent form after the study has been fully explained. - Subjects are willing to cooperate and comply with all of the regulation during the trial. - Subject should inform to investigator immediately if adverse effect is happened. - Subjects are willing to avoid UV overexposure during the trial (include indoor tanning treatment). Exclusion Criteria: - Subjects who have known cosmetic, drug or food allergies. - Subjects who have severe desquamation, tattoo, sunburn, peeling skin or other skin condition might impact measurement. - Subjects with any physical condition judged by the researcher not to be eligible for this study. - Subjects with uncontrollable physical condition such as high blood pressure, thyroid disease, diabetes, etc. - Female who is pregnant or nursing or planning to become pregnant during the course of the study. - Those who are currently participating in other clinical trials or who have just concluded a clinical trial two weeks ago. - Women who have started contraceptive or change current hormone contraceptive methods within 3 months.

Tulokset

Ensisijaiset tulosmittaukset

1. The change of skin moisture [Change from Baseline skin moisture at 8 weeks]

Corneometer® CM825 is utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120

2. The change of skin elasticity [Change from Baseline skin elasticity at 8 weeks]

Cutometer® dual MPA 580 is utilized to measure skin elasticity (parameter R2). Units: μm penetration depth into the probe opening, expressed as curves

3. The change of skin wrinkles [Change from Baseline skin wrinkles at 8 weeks]

3D Full-Face Skin Analyzer IRV is utilized to measure wrinkles. Units: arbitrary units

4. The change of skin collagen density [Change from Baseline skin collagen density at 8 weeks]

DermaLab® combo - 20 MHz High Freq. Ultrasound probe is utilized to scan and analyze skin collagen density. Units: Intensity score

5. The change of skin tone [Change from Baseline skin tone at 8 weeks]

3D Full-Face Skin Analyzer IRV was utilized to measure skin tone. Units: arbitrary units

6. The change of skin brightness [Change from Baseline skin brightness at 8 weeks]

3D Full-Face Skin Analyzer IRV is utilized to measure skin brightness. Units: arbitrary units

7. The change of skin melanin index [Change from Baseline skin melanin index at 8 weeks]

Mexameter® MX 18 is utilized to measure skin melanin index. Units: arbitrary Mexameter® units (0-999)

8. The change of skin L*a*b* value [Change from Baseline skin L*a*b* value at 8 weeks]

Color Spectrophotometer SCM-104/108 is utilized to measure skin L*a*b* value. Units: arbitrary units

Toissijaiset tulosmittaukset

1. The change of transepidermal water loss (TEWL) [Change from Baseline TEWL at 8 weeks]

Tewameter® TM 300 is utilized to measure transepidermal water loss. Units: g/hm²

2. The change of skin texture [Change from Baseline skin texture at 8 weeks]

3D Full-Face Skin Analyzer IRV is utilized to measure skin texture. Units: arbitrary units

3. The change of skin pores [Change from Baseline skin pores at 8 weeks]

3D Full-Face Skin Analyzer IRV is utilized to measure skin pores. Units: arbitrary units

4. The change of skin spots [Change from Baseline skin spots at 8 weeks]

3D Full-Face Skin Analyzer IRV is utilized to measure skin spots. Units: arbitrary units

5. The change of skin erythema level [Change from Baseline skin erythema level at 8 weeks]

Mexameter® MX 18 is utilized to measure skin erythema level. Units: arbitrary Mexameter® units (0-999)

6. Self-assessment questionnaire [8 weeks]

Questionnaire is utilized to assess skin condition of the subjects. Units: score