Biosynthesis of polyphenols functionalized ZnO nanoparticles: Characterization and their effect on human pancreatic cancer cell line.

The present work investigate the green synthesis of zinc oxide nanoparticles (ZnO NPs) using Anacardium occidentale leaf extract by an eco-friendly method. ZnO NPs were synthesized by boiling the mixture of 10 ml of Anacardium occidentale leaf extract and 30 ml 0.1 M zinc nitrate (ZnNO3) at 60 °C for 3 h. The obtained nanoparticles were studied using spectroscopic and microscopic techniques such as Fourier transform-infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDS) and ultraviolet-visible spectroscopy (UV-Vis).X-ray diffraction results showed the hexagonal structure of the ZnO NPs. TEM results confirmed the hexagonal NPs with average particle size of 33 nm. Further the prepared nanoparticles were studied for their cytotoxicity against human pancreatic cancer cells. The cytotoxicity results have confirmed that the fabricated ZnO NPs exhibited the concentration-dependent cytotoxicity against pancreatic cancer cell lines.