Journal of Clinical Pharmacy and Therapeutics 2017-Oct
Cure with ledipasvir/sofosbuvir for chronic hepatitis C virus in an individual with gastric bypass.
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OBJECTIVE
The impact of gastric bypass surgery on the pharmacokinetics of various medications has been reported. Presently, no data exist for the treatment of chronic hepatitis C virus with ledipasvir/sofosbuvir (LDV/SOF) in an individual with a history of gastric bypass.
METHODS
We report the successful cure of an individual who was treated with LDV/SOF who had a history of gastric bypass. The patient tolerated LDV/SOF well while only experiencing a minor headache.
CONCLUSIONS
Ledipasvir/sofosbuvir treatment may still be effective in those with a history of gastric bypass surgery.
