Effects of radiotherapy on parotid salivary sialochemistry in head and neck cancer patients.
Avainsanat
Abstrakti
OBJECTIVE
To determine the effects of high dose irradiation on parotid salivary sodium and pH concentration at subsequent duration of 1.5, 3 and 6 months following radiotherapy.
METHODS
Eighty parotid glands of head and neck cancer patients were irradiated with mean dose of 66 Gy. The stimulated parotid flow (PF) was collected by a cannulation of Stenson's duct followed by analysis of sodium (PF sodium) by Easylyte Sodium/Potassium auto analyzer and pH by litmus narrow band pH paper.
RESULTS
A steep elevation of PF sodium was found in post-RT period after 1.5 months of starting RT followed by gradual increase up to 6 months and pH changed towards acidity.
CONCLUSIONS
A high dose of 66 Gy causes irreversible damage to parotid salivary duct system.