Blood 2010-Oct
GPVI and the not so eager cleaver.
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Abstrakti
Platelets control their responsiveness, in part, by shedding adhesion and signaling receptors from their surface. The molecular mechanism by which this occurs, however,is incompletely understood. In this issue of Blood, Bender and colleagues make judicious use of mice genetically deficient in selected candidate proteases to shed new light on the unexpected complexity of ectodomain shedding.