Merkel Cell Carcinoma With Gastric Metastasis and Review of Literature.

BACKGROUND

Merkel cell carcinoma (MCC) is a rare, highly aggressive cutaneous neoplasm, with a propensity for recurrence and metastasis. Very few cases of metastases to the gastrointestinal tract have been reported in the medical literature.

OBJECTIVE

The aim of this study was to report a case of MCC metastasizing to the stomach, its clinical presentation, and its management.

METHODS

A PubMed search was made using the following search terms: "Merkel cell carcinoma," "gastric," and "metastasis."

RESULTS

The investigators report a case of MCC metastatic to the stomach presenting with melena, syncope, early satiety, increasing fatigue, and unintentional weight loss. The other known cases of gastrointestinal metastasis of MCC are summarized and critically reviewed.

CONCLUSIONS

Although MCC spreading to the stomach is exceedingly rare, because of MCC's high recurrence rate and metastatic potential, it should be considered in patients with histories of MCC presenting with recent weight loss, early satiety, and gastrointestinal bleeding.