Methyl angolensate: the antiulcer agent of the stem bark of Entandrophragma angolense.
Avainsanat
Abstrakti
Methyl angolensate (1), the major compound isolated from the methanol extract of the stem bark of Entandrophragma angolense produced a dose-related inhibition of gastric ulceration, 40 mg/kg body weight (B.W.) being more effective than 40 mg/kg B.W. of propranolol. The highest dose used (80 mg/kg B.W.) completely inhibited gastric ulceration and significantly reduced gastric acidity (P < 0.05). Furthermore, 1 (40 mg/kg B.W.) significantly reduced gastric acid secretion induced by histamine (1.0 mg/kg B.W.) and carbachol (1.0 mg/kg B.W.). These results suggest that 1 produces its antiulcer activity by inhibition of gastric acid secretion.