[Therapeutic efficacy of microsphere-entrapped curcuma aromatica oil infused via hepatic artery against transplanted hepatoma in rats].

OBJECTIVE

To observe the therapeutic efficacy of microsphere-entrapped Curcuma aromatica oil (MS-CAO) infused via hepatic artery against transplanted hepatoma in rats.

METHODS

One hundred duplicated rats bearing transplanted hepatoma were randomly divided into control group, CAO group, blank microsphere (B-MS) group, high-dose and low-dose MS-CAO groups. Each group included twenty rats. Normal saline (0.2-0.3 ml), CAO (10mg/kg), B-MS (10mg/kg) and MS-CAO (10mg/kg, 5mg/kg) were infused from gastroduodenal artery into hepatic artery, in five groups of rats respectively. The survival periods and the tumor growth rates and necrosis grades were compared in rats among five groups.

RESULTS

Compared with the control group of rats, the tumor growth rates were significantly inhibited (1.23% +/- 0.66%, 4.86% +/- 1.47% vs 22.44% +/- 17.81%, F=10.21, P<0.01), the tumor necrosis grades were more extensive (Hc=23.63, P<0.01) and the survival periods were also prolonged (25.50 d +/- 3.89 d, 22.70 d +/- 3.92 d vs 11.70 d +/- 1.89 d, F=36.53, P<0.01) in either high-dose or low-dose MS-CAO group. The therapeutic effects of MS-CAO were superior to either CAO or B-MS.

CONCLUSIONS

The therapeutic efficacy of MS-CAO infused via hepatic artery against hepatoma was much better than that of CAO or B-MS in the rats bearing transplanted hepatoma.