Natural Product Research 2019-Dec
Pro-apoptoticeffect of diterpenoids from Fokienia hodginsii on acute myeloid leukemia cells.
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Abstrakti
Previously, we isolated four known diterpenoids, trans-communic acid (1), 13-oxo-15,16-dinor-labda-8(17), 11E-diene-19-oic acid (2), 3β-hydroxytotarol (3), and totarolone (4) from Fokienia hodginsii leaves. Further study demonstrated the antiproliferative activity of all four compounds in acute myeloid leukemia (OCI-AML) cells due to impaired cell cycle progression. Interestingly, 3β-hydroxytotarol (3) had very powerful bioactivity at low concentrations (5 µg/mL).