Sivu 1 alkaen 27 tuloksia
SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jan. 15, 2015, is named 2009912-0127_SL.txt and is 11,553 bytes in size.
BACKGROUND
Proper
FIELD OF THE INVENTION
This invention relates to novel compounds of the following formulae: ##STR1##
The invention also relates to pharmaceutical compositions comprising a compound of the invention as the active ingredient, a method of treating a physiological condition in mammals that is mediated
FIELD OF THE INVENTION
This invention relates to the use of inhibitors of the renin-angiotensin system.
BACKGROUND OF THE INVENTION
Wasting diseases may be categorized into generalised and localised wasting diseases. To deal first with generalised wasting, many disease processes can lead to
BACKGROUND
The field of the invention relates to angiotensin converting enzyme 2 (ACE2) and variants of ACE2 for reducing plasma levels of Angiotensin II (1-8) and/or for increasing plasma levels of Angiotensin (1-7) in a subject in need thereof. The disclosed variants of ACE2 may include fragments
FIELD OF THE INVENTION
This invention relates to the use of inhibitors of the renin-angiotensin system.
BACKGROUND OF THE INVENTION
Wasting diseases may be categorised into generalised and localised wasting diseases. To deal first with generalised wasting, many disease processes can lead to
FIELD OF THE INVENTION
This invention relates to the use of inhibitors of the renin-angiotensin system.
BACKGROUND OF THE INVENTION
Wasting diseases may be categorised into generalised and localised wasting diseases. To deal first with generalised wasting, many disease processes can lead to
FIELD OF THE INVENTION
This invention relates to the use of inhibitors of the renin-angiotensin system.
BACKGROUND OF THE INVENTION
Wasting diseases may be categorised into generalised and localised wasting diseases. To deal first with generalised wasting, many disease processes can lead to
FIELD OF THE INVENTION
The present invention relates to novel fused heterocyclic compounds having potent pharmacological actions and intermediates for the preparation thereof. More particularly, the present invention relates to fused heterocyclic compounds having potent anti-hypertensive activity
FIELD OF THE INVENTION
This invention relates to novel compounds of the following formula ##STR1## wherein B is a bisfused radical of the following formula ##STR2##
The invention also relates to a pharmaceutical composition comprising a compound of the invention, a method of treating a physiological
This application is a continuation-in-part of PCT/JP93/01134 filed Aug. 11, 1993.
FIELD OF THE INVENTION
The present invention relates to novel biphenylmethane derivatives and salts thereof, said derivatives and salts having a potent angiotensin II antagonist activity and also having a powerful
SUMMARY OF THE INVENTION
The present invention provides pivaloyloxymethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl[benzimidazole-7-carboxylat e having potent anti-hypertensive activity and strong angiotensin II antagonistic action, which are of practical value in clinical use as therapeutic
SUMMARY OF THE INVENTION
The present invention provides 1-acetoxyethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-car boxylate having potent anti-hypertensive activity and strong angiotensin II antagonistic action, which is of practical value in clinical use as
SUMMARY OF THE INVENTION
In a first aspect of the invention there is provided 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-car boxylate, including certain stable forms as well as pharmaceutically acceptable salts, which have
Potent
FIELD OF THE INVENTION
The present invention relates to novel cyclic compounds having excellent pharmacological actions, their intermediates for the synthesis and salts thereof.
More specifically, the present invention relates to a compound represented by the general formula ##STR2## [wherein
TECHNICAL FIELD
This invention relates to novel piperidines derivatives which are of value as a pharmaceutical.
BACKGROUND ART
Although there have been known various compounds exhibiting inhibitory activity on angiotensin converting enzyme, any compound with such activity having a moiety of