Primary Sjogren Syndrome With Multisystem Involvement

no interventional study - Retrospective study that valuate The effect of HCQ treatment in cardiovascular AVENTS IN patients with primary sjogren syndrome

Retrospective study

the Effect of HCG Treatment as a Cardiovascular Disease Morbidity Factor in Sjogren Syndrome Patients

Retrospective Study That Evaluate the Effect of HCG Treatment as a Cardiovascular Disease Morbidity Factor in Patients With Primary Sjogren Syndrome

yair levy

professor - head of internal medicine department

Meir Medical Center

Delayed addition of hydroxychloroquine in patients with discordant CD4+ cell responses to suppressive HAART

Immediate addition of hydroxychloroquine in patients with discordant CD4+ cell responses to suppressive HAART

HIV Infection

Hydroxychloroquine 400mg once daily orally

Hydroxychloroquine

St Stephen's Centre

Hydroxychloroquine for Discordant CD4 Responders on Highly Active Antiretroviral Therapy (HAART)

The Immunological Impact of Adding Hydroxychloroquine in Patients With Discordant CD4+ Cell Responses to Suppressive HAART: A Phase I Pilot Study.

To measure the change in CD4 from baseline after 12 weeks of hydroxychloroquine therapy

St Stephens Aids Trust

This arm of the study will contain half the study population after randomization. The participants in this arm will receive hydroxychloroquine for 8 weeks and then crossover to a placebo for 8 weeks. Study staff will be blinded to which order they are taking the hydroxychloroquine and placebo in.

This arm of the study contains half the study population after randomization. The participants in this arm received hydroxychloroquine for 8 weeks and then crossed over to a placebo for 8 weeks. Study staff was blinded to which order they were taking the hydroxychloroquine and placebo in.
Hydroxychloroquine: Hydroxychloroquine comes in 200 mg tablets and is taken orally. The dose provided will be based upon a calculation of 6.5 mg/kg (subject's weight), which is the dose range commonly used to treat rheumatoid arthritis and lupus. Dosages will be rounded to the nearest 100 mg.

HCQ Then Placebo

Placebo Then HCQ

Total

Sex: Female, Male

We will examine the effect of HCQ on the Matsuda Insulin Sensitivity Index (ISI) during the active treatment phase compared with placebo phase.
ISI is based on insulin and glucose levels in a fasting state during an oral glucose tolerance test (OGTT) and is calculated as follows:
ISI (Matsuda) = 10000/√ G0 X I0 X Gmean X Imean
G0 - fasting plasma glucose (mg/dL) I0 - fasting plasma insulin (mIU/L) Gmean - mean plasma glucose during OGTT (mg/dL) Imean - mean plasma insulin during OGTT (mIU/L)

This group contains results for when study participants were taking hydroxychlorquine.
Hydroxychloroquine: Hydroxychloroquine comes in 200 mg tablets and is taken orally. The dose provided was based upon a calculation of 6.5 mg/kg (subject's weight), which is the dose range commonly used to treat rheumatoid arthritis and lupus. Dosages will be rounded to the nearest 100 mg.

This arm group contains the results for patients while they were on placebo.

Placebo

Insulin Sensitivity Index

We will examine the effect of HCQ on HOMA-IR during the active treatment phase compared with placebo phase.
HOMA-IR = (Glucose x insulin)/405

HOMA-IR

HOMA-B

Total Cholesterol

LDL Cholesterol

HDL Cholesterol

Triglycerides

First Intervention (8 Weeks)

Second Intervention (8 Weeks)

Dr. Daniel H. Solomon

Participants received hydroxychloroquine (HCQ) for 8 weeks.
Hydroxychloroquine: Hydroxychloroquine comes in 200 mg tablets and is taken orally. The dose provided will be based upon a calculation of 6.5 mg/kg (subject's weight), which is the dose range commonly used to treat rheumatoid arthritis and lupus. Dosages will be rounded to the nearest 100 mg.

Participants received Placebo tablets for 8 weeks.

Rheumatoid Arthritis

Insulin Resistance

Hydroxychloroquine comes in 200 mg tablets and is taken orally. The dose provided will be based upon a calculation of 6.5 mg/kg (subject's weight), which is the dose range commonly used to treat rheumatoid arthritis and lupus. Dosages will be rounded to the nearest 100 mg.

antimalarial/infarkti

the Effect of HCG Treatment as a Cardiovascular Disease Morbidity Factor in Sjogren Syndrome Patients

Hydroxychloroquine for Discordant CD4 Responders on Highly Active Antiretroviral Therapy (HAART)

Hydroxychloroquine to Improve Insulin Sensitivity in Rheumatoid Arthritis

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