patients treated with Riboflavin at 4ºC in crosslinking (cases).

patients treated with Riboflavin at room temperature in crosslinking (controls)

Keratoconus

Crosslinking

Crosslinking in patients with progressive keratoconus.

corneal collagen crosslinking

Instituto de oftalmología conde de Valenciana

Riboflavin at 4ºC for the Management of Pain After Crosslinking for Keratoconus Patients

A previously validated numerical pain scale questionnaire was applied. Patients are asked to indicate their pain intensity on a scale of 0 to 10, explaining that 0 does not represent pain at all and 10 is a severe and disabling pain.

Instituto de Oftalmología Fundación Conde de Valenciana

Participants will complete the 4 week intervention, 4 week washout, then 4 week control period (monitor only)

Participants will complete the 4 week control period (monitor only), 4 week washout, then 4 week intervention

Colon Cancer Prevention

Participants will be provided frozen dark leafy green vegetables, and counseled to consume 1 cup cooked dark green leafy vegetables (2 servings) daily over the 4 week period while maintaining their normal red meat intake. This will occur during the first 4 week period of the study.

High chlorophyll diet - intervention 1st

Participants will be provided frozen dark leafy green vegetables, and counseled to consume 1 cup cooked dark green leafy vegetables (2 servings) daily over the 4 week period while maintaining their normal red meat intake. This will occur during the last 4 week period of the study.

High chlorophyll diet - control 1st

Meat and Three Greens website and link to eligibility survey

Auburn University

Exploring the Effects of a High Chlorophyll Dietary Intervention to Reduce Colon Cancer Risk in Adults

Exploring the Effects of a High Chlorophyll Dietary Intervention to Reduce Colon Cancer Risk in Adults: The Meat and Three Greens Feasibility Trial

Retain 90% of sample at crossover and 80% at completion

Meet chlorophyll intake goals 90% of days

16s changes in microbiota alpha diversity

Body fat percentage using Bioelectrical Impedence Analysis

Acceptability of the diets will be measured by the Food Acceptability Questionnaire (FAQ) total score. The FAQ is a 10 item questionnaire scored on a 7-point likert scale with total scores ranging from 7-70.

Andrew Fruge

Assistant Professor and Director, Didactic Program in Dietetics

4 week intervention and control periods will be delivered and separated by a 4 week washout. The order of intervention and control periods will be randomly allocated

After randomization, Investigators will give human milk fortiﬁed with olive oil

After randomization, Human milk fortiﬁed with Eoprotin according to the recommendations of the manufacturer (1g per 30ml milk)

Breast Milk Expression

Premature Birth of Newborn

The infants fed with olive oil will have received same amount of calorie with infants who will receive eoprotin-fortified breast milk.

olive oil

Low birth weight infants are premature infants that born with birth weight less than 1500 g. Because these infants have low birth weight, weight gain can be increased by fortifying breast milk after post-natal 7 with eoprotin.

Eoprotin

How Effect Olive Oil and Eoprotin on Immunological Parameters and Growth

The Effect on Immunological Parameters and Growth of Olive Oil and Eoprotin Used as a Fortification Breast Milk at the VLBW Babies

For 45 days, 30 patients will receive eoprotin as breast milk fortifier while another 30 patients will receive olive oil, then 3 cc of blood will be taken from all patients at 0, 15., 30. and 45. days into biochemistry vials and will be stored at -80 C after centrifuge.
At the end of the study, participants will be analyzed tumor necrosis factor alpha with ELISA method by BIO-Tec ELx800 Absorbance Reader device ;

For 45 days, 30 patients will receive eoprotin as breast milk fortifier while another 30 patients will receive olive oil, then 3 cc of blood will be taken from all patients at 0, 15., 30. and 45. days into biochemistry vials and will be stored at -80 C after centrifuge.
At the end of the study, participants will be analyzed IL-1 with ELISA method by BIO-Tec ELx800 Absorbance Reader device ;

For 45 days, 30 patients will receive eoprotin as breast milk fortifier while another 30 patients will receive olive oil, then 3 cc of blood will be taken from all patients at 0, 15., 30. and 45. days into biochemistry vials and will be stored at -80 C after centrifuge.
At the end of the study, participants will be analyzed IL-6 with ELISA method by BIO-Tec ELx800 Absorbance Reader device ;

For 45 days, 30 patients will receive eoprotin as breast milk fortifier while another 30 patients will receive olive oil, then 3 cc of blood will be taken from all patients at 0, 15., 30. and 45. days into biochemistry vials and will be stored at -80 C after centrifuge.
At the end of the study, participants will be analyzed IL-8 with ELISA method by BIO-Tec ELx800 Absorbance Reader device ;

For 45 days, 30 patients will receive eoprotin as breast milk fortifier while another 30 patients will receive olive oil, then 3 cc of blood will be taken from all patients at 0, 15., 30. and 45. days into biochemistry vials and will be stored at -80 C after centrifuge.
At the end of the study, participants will be analyzed IL-10 with ELISA method by BIO-Tec ELx800 Absorbance Reader device ;

For 45 days, 30 patients will receive eoprotin as breast milk fortifier while another 30 patients will receive olive oil, then 3 cc of blood will be taken from all patients at 0, 15., 30. and 45. days into biochemistry vials and will be stored at -80 C after centrifuge.
At the end of the study, participants will be analyzed triglyceride with spectrophotometric method by Architect ci16200;

For 45 days, 30 patients will receive eoprotin as breast milk fortifier while another 30 patients will receive olive oil, then 3 cc of blood will be taken from all patients at 0, 15., 30. and 45. days into biochemistry vials and will be stored at -80 C after centrifuge.
At the end of the study, participants will be analyzed total cholesterol with spectrophotometric method by Architect ci16200;

For 45 days, 30 patients will receive eoprotin as breast milk fortifier while another 30 patients will receive olive oil, then 3 cc of blood will be taken from all patients at 0, 15., 30. and 45. days into biochemistry vials and will be stored at -80 C after centrifuge.
At the end of the study, participants will be analyzed Low density lipoprotein (LDL) with spectrophotometric method by Architect ci16200;

For 45 days, 30 patients will receive eoprotin as breast milk fortifier while another 30 patients will receive olive oil, then 3 cc of blood will be taken from all patients at 0, 15., 30. and 45. days into biochemistry vials and will be stored at -80 C after centrifuge.
At the end of the study, participants will be analyzed High density lipoprotein (HDL) with spectrophotometric method by Architect ci16200;

will be defined according to National Institutes of Health criteria.

Chronic Lung Disease (CLD) will be defined according to National Institutes of Health criteria.

Echocardiography will be performed routinely for patent ductus arteriosus within 5 days of life

We will assess for intraventricular haemorrhage higher than grade II using the Papile classification system

Necrotising enterocolitis with the modified Bell's classification system

Retinopathy of prematurity (ROP) defined based on the criteria of the American Academy of Pediatrics, American Academy of Ophthalmology and American Association for Pediatric Ophthalmology and Strabismus.

nihat demir

Principal Investigator

Dietary Modification

Cardiovascular Disease

One capsule, twice daily with meals for 28 days

Chlorophyll complex, Standard Process

One capsule per day with meals for 28 days

Betatene, sold as "Full Spectrum Carotenoid Complex"

Single carotenoid-enriched soup or salad serving eaten daily

Small carotenoid-rich meals

Safflower oil-filled capsules, one twice daily with meals

chlorophyll/tulehdus

Riboflavin at 4ºC for the Management of Pain After Crosslinking for Keratoconus Patients

Exploring the Effects of a High Chlorophyll Dietary Intervention to Reduce Colon Cancer Risk in Adults

How Effect Olive Oil and Eoprotin on Immunological Parameters and Growth

Feeding the Rainbow to Investigate Endothelial Dysfunction

Täydellisin lääketieteellinen tietokanta tieteen tukemana