Group of ladies who will undergo testing, receive dietary intervention, and take cinnamon supplements.

Group of ladies who will undergo testing, receive dietary intervention, but will not get cinnamon supplements.

Insulin Resistance

cinnamon twice daily plus follow Cardiometabolic diet

Food plan with cinnamon supplementation

Food plan without cinnamon supplementation

Woman's Hospital

Improving Insulin Resistance in Gynecological Cancer Patients

Improving Insulin Resistance in Gynecological Cancer Patients Post Treatment Using Integrative and Functional Food Plan With or Without Cinnamon Supplementation

To determine whether the addition of cinnamon to the implementation of an integrative and functional (IF) food plan will show a difference of 10 mg% in the mean glucose concentration measured when comparing the baseline and 24 week Oral Glucose Tolerance Test (OGTT) glucose levels.

To determine whether the addition of cinnamon to the implementation of an IF food plan will improve BMI more than just dietary intervention alone. BMI will be calculated by dividing the participant's weight by her height squared.

To determine whether the addition of cinnamon to the implementation of an IF food plan will improve the ratio of fat mass to fat free mass more than just dietary intervention alone. We will measure using a Fit3D scanner that uses infrared cameras to estimate fat mass and fat free mass.

To determine whether the addition of cinnamon to the implementation of an IF food plan will improve glucose tolerance levels more than just dietary intervention alone. It will be measured using the results of the baseline and final 2-hour Oral Glucose Tolerance Test which measures glucose and insulin at 4 time points.

Brooke Schoonenberg

Nutrition Services Manager

Woman's

Woman's Hospital, Louisiana

Dietitians in Integrative and Functional Medicine DPG

PCOS patients receiving abstract of cinnamon

Purified aqueous abstract of cinnamon in 125mg capsules
Cinnamon Extract: Purified aqueous abstract of cinnamon in 125mg capsules, which would be taken orally before each meal, for a total of 1,500mg/day for 6 months.

Cinnamon Extract Arm

Placebo capsules containing ground cereal.
Placebo: Placebo capsules containing ground cereal.

Placebo Arm

Total

Sex: Female, Male

Ethnicity (NIH/OMB)

Region of Enrollment

Ovulatory cycles will be confirmed by serum progesterone levels.

Purified aqueous abstract of cinnamon in 125mg capsules
Cinnamon Extract: Purified aqueous abstract of cinnamon in 125mg capsules, which would be taken orally before each meal, for a total of 1,500mg/day for 6 months.
Baseline (no. of cycles/month) 0.42 Study period (no. of cycles/month) 0.75 Change during study +/- cycles/month +0.23

Placebo capsules containing ground cereal.
Placebo: Placebo capsules containing ground cereal.
Baseline (no. of cycles/month) 0.42 Study period (no. of cycles/month) 0.25 Change during study +/- cycles/month -0.13

Number of Menses During the Six Month Study Period.

The changes in insulin resistance parameters in overweight patients with PCOS between baseline and after 6 months of daily cinnamon compared to the corresponding change in patients receiving 6 months of placebo. Higher values of insulin resistance represent a worse outcome. A higher value Homeostasis Model of Insulin Resistance indicates more insulin resistance so higher values are worse outcomes (a score of >2 is considered healthy for adults with scores >5 being considered severe insulin resistance). For the Quant. Insulin Sensitivity Check Index, a lower value indicates more insulin resistance so lower values are worse outcomes (values can range from .45, which is considered normal in health individuals and .30, which is characteristic of diabetes).

Change in Insulin Resistance

Change in Glucose Response - area under the curve (AUC), trapezoidal method - in overweight patients with PCOS between baseline and after 6 months of daily cinnamon compared to the corresponding change in patient receiving 6 months of placebo. Fasting blood samples were drawn followed by a 2 hour glucose tolerance test with blood draws at 30, 60, and 120min post glucose ingestion.

Change in Glucose Response

Overall Study

Roger A. Lobo M.D.

PCOS patients receiving extract of cinnamon
Cinnamon Extract: Purified aqueous abstract of cinnamon in 125mg capsules, which would be taken orally before each meal, for a total of 1,500mg/day for 6 months.

PCOS patients receiving placebo capsules
Placebo: Placebo capsules containing ground cereal.

Polycystic Ovary Syndrome

Purified aqueous abstract of cinnamon in 125mg capsules, which would be taken orally before each meal, for a total of 1,500mg/day for 6 months.

Cinnamon Extract

Placebo capsules containing ground cereal.

Placebo

Columbia University Medical Center

Cinnamon Extract on Menstrual Cycles in PolyCystic Ovary Syndrome (PCOS)

The Effects of Oral Cinnamon Extract on Menstrual Cyclicity in PolyCystic Ovary Syndrome

Rogerio A. Lobo

Professor of Obstetrics and Gynecology

Integrity Nutraceuticals International

A purified aqueous abstract of cinnamon in a 500mg tablet will be taken by each patient before lunch and dinner, making a total of one gram per day for eight weeks.

Oral Cinnamon Extract

Placebo pills in likeness of the cinnamon extract

cinnamon/syöpä

Improving Insulin Resistance in Gynecological Cancer Patients

Cinnamon Extract on Menstrual Cycles in PolyCystic Ovary Syndrome (PCOS)

The Effect of Cinnamon Extract on Insulin Resistance Parameters in Polycystic Ovary Syndrome: A Pilot Study

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