Standard therapy in the form of home quarantine for 2 weeks along with social distancing and personal hygiene Plus Tablet HCQ 400 mg q 12 hourly on day one followed by 400 mg once weekly for 3 weeks (total cumulative dose of 2000 mg)

Standard therapy in the form of home quarantine for 2 weeks along with social distancing and personal hygiene

CoVID-19

Tablet HCQ 400 mg q 12 hourly on day one followed by 400 mg once weekly for 3 weeks (total cumulative dose of 2000 mg)

Home quarantine for 2 weeks plus social distancing plus personal hygiene

Standard therapy

Post Graduate Institute of Medical Education and Research (PGIMER)

Post Graduate Institute of Medical Education and Research

Efficacy of Hydroxychloroquine (HCQ) as Post Exposure Prophylaxis (PEP) for Prevention of COVID-19

Efficacy of Hydroxychloroquine (HCQ) as Post Exposure Prophylaxis (PEP) for Prevention of COVID-19 in Asymptomatic Individual at Risk for SARS-CoV-2 Infection-A Open Level Control Clinical Trial

Symptomatic individual with RTPCR positive for SARS-CoV-2 will be defined as confirmed COVID-19 case

Symptomatic individual with RTPCR negative for SARS-CoV-2 will be defined as probable COVID-19 case.

Any adverse reaction related to Hydroxychloroquine

Data will be shared with the concerned authority and Institutional Ethics committee as and when required.

Deba Prasad Dhibar

Assistant Professor

Postgraduate Institute of Medical Education and Research

Intervention consists of daily administration of 2g probiotic Lactobacillus casei Zhang, administered daily at a fixed dosage of 9 log CFU/sachet/day and continue for 12 months.

Intervention consists of daily administration of 2g placebo (no probiotic bacteria), administered daily and continue for 12 months.

Healthy Volunteers

This project aims to study the benefits of probiotics namely Lactobacillus casei Zhang in prevention of upper respiratory and gastrointestinal illnesses, among adults in Malaysia aged from 18-81 years.

Lactobacillus casei Zhang

Placebo

School of Industrial Technology, Universiti Sains Malaysia

Effects of Lactobacillus Casei on Respiratory and Gastrointestinal Diseases in Adults

Effects of Lactobacillus Casei in the Prevention of Upper Respiratory and Diarrheal Diseases Among Adults

IgA as an indicator for immunology, in assessing severity of upper respiratory illnesses between number of adult participants taking LCZ vs. placebo

Bristol stool scale (from a scale of 1-7; scale of 1 representing hard lump, and 7 representing liquid with no solid pieces) as an indicator for assessing severity of gastrointestinal-related diarrheal illnesses between number of adult participants taking LCZ vs. placebo

Deoxyribonucleic acid (DNA) sequencing of fecal samples to compare DNA sequences of the different microbiota between adult participants taking LCZ vs. placebo

croup/ripuli

Efficacy of Hydroxychloroquine (HCQ) as Post Exposure Prophylaxis (PEP) for Prevention of COVID-19

Effects of Lactobacillus Casei on Respiratory and Gastrointestinal Diseases in Adults

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