Insulin resistance / tyrosine

Benzo[b]thiophenyl or tetrahydro-benzo[b]thiophenyl modulators of protein tyrosine phosphatases (PTPases)

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FIELD OF THE INVENTION The present invention relates to novel compounds, to methods for their preparation, to compositions comprising the compounds, to the use of these compounds as medicaments and their use in therapy, where such compounds of Formula 1 are pharmacologically useful inhibitors of

RNA interference mediated inhibition of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)

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SEQUENCE LISTING The sequence listing submitted via EFS, in compliance with 37 CFR .sctn.1.52(e)(5), is incorporated herein by reference. The sequence listing text file submitted via EFS contains the file "SequenceListing6USCNT3," created on Feb. 17, 2010, which is 341,760 bytes in size. FIELD OF

Antagonists to insulin receptor tyrosine kinase inhibitor

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FIELD OF THE INVENTION The present invention relates to agents that neutralize the activity of inhibitors of insulin receptor tyrosine kinase activity, especially PC-1, and their uses in the diagnosis and treatment of diseases and disorders involving inappropriate insulin receptor tyrosine kinase

Antagonists to insulin receptor tyrosine kinase inhibitor

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FIELD OF THE INVENTION The present invention relates to agents that neutralize the activity of inhibitors of insulin receptor tyrosine kinase activity, especially PC-1, and their uses in the diagnosis and treatment of diseases and disorders involving inappropriate insulin receptor tyrosine kinase

Inhibitors of protein tyrosine phosphatase 1B

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TECHNICAL FIELD This invention relates to inhibitors of protein tyrosine phosphatase 1B (PTP1B) and other protein tyrosine phosphatases (PTPases). BACKGROUND Protein tyrosine phosphatases (PTPases) are a large family of diverse molecules that can play an important role in modulating a wide variety

Modulators of protein tyrosine phosphatases (PTPases)

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FIELD OF THE INVENTION The present invention relates to novel thienopyridines, to methods for their preparation, to compositions comprising the compounds, to the use of these compounds as medicaments and their use in therapy, where such compounds of Formula 1 are pharmacologically useful inhibitors

Modulators of protein tyrosine phosphateses (PTPases)

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FIELD OF THE INVENTION The present invention relates to novel compounds, to methods for their preparation, to compositions comprising the compounds, to the use of these compounds as medicaments and their use in therapy, where such compounds of Formula 1 are pharmacologically useful inhibitors of

Modulators of Protein Tyrosine Phosphatases (PTPases)

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FIELD OF THE INVENTION The present invention relates to novel compounds, to methods for their preparation, to compositions comprising the compounds, to the use of these compounds as medicaments and their use in therapy, where such compounds of Formula 1 are pharmacologically useful inhibitors of

Modulators of protein tyrosine phosphatases (PTPases)

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FIELD OF THE INVENTION The present invention relates to novel compounds, to methods for their preparation, to compositions comprising the compounds, to the use of these compounds as medicaments and their use in therapy, where such compounds of Formula 1 are pharmacologically useful inhibitors of

Modulators of protein tyrosine phosphatases (PTPASES)

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FIELD OF THE INVENTION The present invention relates to novel compounds, to methods for their preparation, to compositions comprising the compounds, to the use of these compounds as medicaments and their use in therapy, where such compounds of Formula 1 are pharmacologically useful inhibitors of

Protein tyrosine phosphatase inhibitors and methods of use thereof

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FIELD OF THE INVENTION This invention relates to the field of protein tyrosine phosphatase inhibition. BACKGROUND OF THE INVENTION This invention relates to a novel class of phosphonic acid derivatives that are inhibitors of PTP-1B. Reversible protein tyrosine phosphorylation, coordinated by the

Protein tyrosine phosphatase inhibitors and methods of use thereof

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FIELD OF THE INVENTION This invention relates to the field of protein tyrosine phosphatase inhibition. BACKGROUND OF THE INVENTION This invention relates to a novel class of phosphonic acid derivatives that are inhibitors of PTP-1B. Reversible protein tyrosine phosphorylation, coordinated by the

Modulators of protein tyrosine phosphatases (PTPases)

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FIELD OF THE INVENTION The present invention relates to novel compounds, to methods for their preparation, to compositions comprising the compounds, to the use of these compounds as medicaments and their use in therapy, where such compounds of Formula 1 are pharmacologically useful inhibitors of

Antibodies specific for intracellular domain of protein tyrosine phosphatase

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FIELD OF THE INVENTION The present invention relates to antibodies that specifically bind to intracellular domains of two or more kinds of protein tyrosine phosphatases (hereinafter referred to as PTPs) and to methods for generating the same. More particularly, the present invention relates to

1,2,5-thiazolidine derivatives useful for treating conditions mediated by protein tyrosine phosphatases (PTPase)

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This application is the National Stage of Application No. PCT/EP2006/046543, filed on Dec. 6, 2006, which claims benefit under 35 U.S.C. .sctn.119(a-d) of U.S. Provisional Application No. 60/748,491, filed Dec. 8, 2005, the contents of which are incorporated herein by reference in their

insulin resistance/tyrosine

Benzo[b]thiophenyl or tetrahydro-benzo[b]thiophenyl modulators of protein tyrosine phosphatases (PTPases)

RNA interference mediated inhibition of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)

Antagonists to insulin receptor tyrosine kinase inhibitor

Antagonists to insulin receptor tyrosine kinase inhibitor

Inhibitors of protein tyrosine phosphatase 1B

Modulators of protein tyrosine phosphatases (PTPases)

Modulators of protein tyrosine phosphateses (PTPases)

Modulators of Protein Tyrosine Phosphatases (PTPases)

Modulators of protein tyrosine phosphatases (PTPases)

Modulators of protein tyrosine phosphatases (PTPASES)

Protein tyrosine phosphatase inhibitors and methods of use thereof

Protein tyrosine phosphatase inhibitors and methods of use thereof

Modulators of protein tyrosine phosphatases (PTPases)

Antibodies specific for intracellular domain of protein tyrosine phosphatase

1,2,5-thiazolidine derivatives useful for treating conditions mediated by protein tyrosine phosphatases (PTPase)

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