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ischemia/päänsärky

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Method of treating migraine headache without aura

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TECHNICAL FIELD OF THE INVENTION The present invention relates to methods and compositions for treating selected conditions of the central and peripheral nervous systems employing non-synaptic mechanisms. More specifically, one aspect of the present invention relates to methods and compositions for

Cyclohexylamine derivatives as subtype selective N-Methyl-D-Aspartate antagonists

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FIELD OF THE INVENTION The invention provides cyclohexylamine derivatives as N-Methyl-D-Aspartate (NMDA) antagonists, pharmacological compositions comprising the derivatives, and methods of treating diseases and disorders responsive to antagonism of NMDA receptors using the derivatives. BACKGROUND

Systems, devices and methods for the treatment of neurological disorders and conditions

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TECHNICAL FIELD The present disclosure generally relates to cutaneous neurostimulator systems, devices and methods of using the same and more particularly relates to cutaneous neurostimulator systems, devices and methods for treating or promoting recovery from neurological disorders or conditions,

Systems, devices and methods for the treatment of neurological disorders and conditions

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TECHNICAL FIELD The present disclosure generally relates to cutaneous neurostimulator systems, devices and methods of using the same and more particularly relates to cutaneous neurostimulator systems, devices and methods for treating or promoting recovery from neurological disorders or conditions,

Systems, devices and methods for the treatment of neurological disorders and conditions

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This application is also related to the following copending applications: U.S. application Ser. No. 12/898,685, entitled "Extracranial Implantable Devices, Systems and Methods for Treatment of Neuropsychiatric Disorders," filed on even date herewith with U.S. application Ser. No. 12/898,686,

4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists

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BACKGROUND OF THE INVENTION 1. Field of the Invention This invention is related to 4-substituted piperidine analogs, including hydroxypiperidine and tetrahydropyridine analogs, as well as novel intermediates of the 4-substituted analogs. The analogs are selectively active as antagonists of

4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists

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BACKGROUND OF THE INVENTION 1. Field of the Invention This invention is related to 4-substituted piperidine analogs, including hydroxypiperidine and tetrahydropyridine analogs, as well as novel intermediates of the 4-substituted analogs. The analogs are selectively active as antagonists of

2-substituted piperidine analogs and their use as subtype-selective NMDA receptor antagonists

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BACKGROUND OF THE INVENTION 1. Field of the Invention This invention is related to 2-substituted piperidine analogs. The analogs are selectively active as antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes. The invention is also directed to the use of 2-substituted piperidine analogs as

2-substituted piperidine analogs and their use as subtype-selective NMDA receptor antagonists

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BACKGROUND OF THE INVENTION 1. Field of the Invention This invention is related to 2-substituted piperidine analogs. The analogs are selectively active as antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes. The invention is also directed to the use of 2-substituted piperidine analogs as

4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists

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BACKGROUND OF THE INVENTION 1. Field of the Invention This invention is related to 4-substituted piperidine analogs, including hydroxypiperidine and tetrahydropyridine analogs. The analogs are selectively active as antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes. The invention is also

Piperidine derivatives as subtype selective N-Methyl-D-Aspartate antagonists

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FIELD OF INVENTION The invention relates to piperidine derivatives as N-Methyl-D-Aspartate (NMDA) antagonists useful in the treatment of diseases and disorders responsive to antagonism of NMDA receptors. BACKGROUND OF THE INVENTION Many of the physiological and pathophysiological effects of the

Process of using anti-inflammatory furanones as selective calcium channel inhibitors

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BACKGROUND Manoalide is a compound isolated from a marine sponge [E. D. de Silva et al., Tetrahedron Letters 21:1611-1614 (1980)] which has anti-inflammatory, immunosuppressive and analgesic properties. Manoalide the structure of which is shown below, includes a 5-hydroxy-2(5H)-furanone moiety,

Method for pain relief using low power laser light

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BACKGROUND OF THE INVENTION Although it is often said that the common cold is the most prevalent disease among humankind, it is also true that chronic pain is an affliction that is almost as prevalent. Chronic headaches, muscle pain, joint pain, and the like are experienced by most individuals, and

Amines that inhibit a mammalian anandamide transporter, and methods of use thereof

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BACKGROUND OF THE INVENTION Mammalian Endogenous Cannabinoid System The various elements of the mammalian endogenous cannabinoid system (ECS) constitute a variety of pharmacological targets for the broad group of compounds generally termed as cannabinoids. Included among these elements are two types

Amines that inhibit a mammalian anandamide transporter, and methods of use thereof

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BACKGROUND OF THE INVENTION Mammalian Endogenous Cannabinoid System The various elements of the mammalian endogenous cannabinoid system (ECS) constitute a variety of pharmacological targets for the broad group of compounds generally termed as cannabinoids. Included among these elements are two types
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