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[CHANGES IN THE FOLLICULAR APPARATUS AND BLOOD VESSELS OF THE OVARIES IN RATS INDUCED BY MELATONIN UNDER CONDITIONS OF HYPERTHERMIA].
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The study was conducted on 155 female Wistar rats (aged 3 months, body mass--180-200 g), in diestrus phase of the sexual cycle. The effect of the pineal hormone melatonin (MT) on morphological organization of the follicular apparatus and the vasculature of the ovaries was studied in rats after
Melatonin and its day and night rhythm of alterations in familial mediterranean Fever: a brief research letter.
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OBJECTIVE
The pineal hormone melatonin plays a crucial role in immunomodulation, mainly by effecting T cells. The aims of the present study were to compare the melatonin levels in patients with Familial Mediterranean Fever (FMF) and healthy controls and to find out if it associates with
Melatonin regulates energy balance and attenuates fever in Siberian hamsters.
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Fever is considered an important host defense response but requires significant metabolic energy. During winter many animals must balance immune function with competing physiological demands (i.e. thermoregulation) to survive. Winterlike patterns of melatonin secretion induce a number of
Effect of melatonin on cytokine levels in a hyperthermia-induced febrile seizure model.
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Higher serum cytokine levels have been reported in children admitted with febrile seizures and in some experimental models. However, other studies have shown that cytokine levels are influenced by melatonin. In this study, we investigated serum cytokine levels in a hyperthermia-induced febrile rat
Alleviation of maternal hyperthermia-induced early embryonic death by administration of melatonin to mice.
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Maternal hyperthermia induces early embryonic death via increased oxidative stress to the embryo. In this study, we examined whether melatonin administered to heat-stressed pregnant mice would reduce hyperthermia-induced embryonic death. Mice were heat stressed (12 hr at 35 degrees C, 60% relative
Melatonin effects on inhibition of thirst and fever induced by lipopolysaccharide in rat.
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In 24 h water deprived rats we have evaluated the effects of melatonin on the inhibition of thirst and on fever induced by Escherichia coli lipopolysaccharide. Intraperitoneal (i.p) injection of lipopolysaccharide (0.32, 0.64 and 0.96 mg/kg) alone induced, a dose-dependent and significant inhibition
Role of centrally administered melatonin and inhibitors of COX and NOS in LPS-induced hyperthermia and adipsia.
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In the present study we have examined the effect of centrally administered non-steroidal anti-inflammatory drugs (NSAIDS), nitric oxide synthase (NOS) inhibitor and melatonin on lipopolysaccharide (LPS)-induced hyperthermia and its anti-dipsogenic effect. Intracerebroventricular (i.c.v.)
Sustained melatonin treatment blocks body mass, pelage, reproductive, and fever responses to short day lengths in female Siberian hamsters.
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Winter imposes physiological challenges on individuals including increased thermoregulatory demands, risk of infection, and decreased food availability. To survive these challenges, animals living outside the tropics must appropriately distribute their energetic costs across the year, including
Melatonin enhances hyperthermia-induced apoptotic cell death in human leukemia cells.
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Melatonin is an endogenous indoleamine with a wide range of biological functions. In addition to modulating circadian rhythms, it plays important roles in the health as an antioxidant. Melatonin has also the ability to induce apoptosis in cancer cells and to enhance the antitumoral activity of
Role of Melatonin Receptors in Hyperthermia-Induced Acute Seizure Model of Rats.
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Melatonin is a neurohormone that has anticonvulsant activity in different experimental seizure models including hyperthermic febrile seizure. However, the mechanisms of this effect are not clear at the receptor level. The aim of the study was to determine which melatonin receptors involve in the
[The reduced level of plasma melatonin in HFRS patients is correlated with disease severity and stage].
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Objective To investigate the changes of plasma melatonin (MLT) level in patients with hemorrhagic fever with renal syndrome (HFRS) and the relationships between the MLT level and the disease stage or severity. Methods The plasma samples were collected from 14 HFRS patients at acute stage or
Ameliorative effects of melatonin administration and photoperiods on diurnal fluctuations in cloacal temperature of Marshall broiler chickens during the hot dry season.
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Experiments were performed with the aim of determining the effect of melatonin administration on diurnal fluctuations in cloacal temperature (CT) of Marshall broiler chickens during the hot dry season. Birds in group I (12L:12D cycle) were raised under natural photoperiod of 12-h light and 12-h
Melatonin in epilepsy and febrile seizures.
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A study on melatonin rhythm in children with generalized idiopathic epilepsy and simple fever is presented in this article. A population of 40 children was divided into 4 groups, namely, epilepsy, febrile seizure, and 2 control groups. Salivary melatonin was measured by means of radioimmunoassay.
Thermotrophic effect of melatonin in adrenalectomized and thyroidectomized rats.
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A single injection of 25 micrograms melatonin induced hyperthermia in rats. The mechanism(s) by which melatonin induces hyperthermia is not clear. In this study the thermotrophic effects of melatonin were studied in adrenalectomized (ADX) and thyroidectomized (TX) rats to ascertain if
Modification of cutaneous vasodilator response to heat stress by daytime exogenous melatonin administration.
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In humans, the nocturnal fall in internal temperature is associated with increased endogenous melatonin and with a shift in the thermoregulatory control of skin blood flow (SkBF), suggesting a role for melatonin in the control of SkBF. The purpose of this study was to test whether daytime exogenous
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