Skull Base Neoplasms

Assiut University

Skull Base Reconstruction After Endonasal Cranio-endoscopic Resection Using Autologus Grafts

bone window axial, coronal and sagittal cuts to measure preoperative skull base defect size

Coronal, axial and sagittal MRI in T1 and T2 signals measures postoperative tumor, to assess the repaired defect after the surgery

Coronal, axial and sagittal MRI in T1 and T2 signals to assess the repaired defect after the surgery

Coronal, axial and sagittal MRI in T1 and T2 signals to assess the repaired defect after the surgery, recurrence of tumor

identification of possible complication that will occur during resection of skull base and removal of tumors

history of CSF leakage confirmed by endoscopic examination

second surgical intervention to explore the grafted defect

using 4 mm 0-degree endoscope to measure graft condition and visualize any CSF fistula

Coronal, axial and sagittal MRI in T1 and T2 signals measures preoperative tumor size

identification of the type of the pathology

Ahmed Gamal Sholkamy

All Groups

Sex/Gender, Customized

Region of Enrollment

Adverse Events assessed in accordance with CTCAE (NCI Common Terminology Criteria for Adverse Events) Version 3.0.

Number of Participants Experiencing Serious Adverse Events Including But Not Limited to Hospitalizations, Deaths Related to Treatment, or Other Incapacitating Conditions.

Response and progression will be evaluated in this study using measurements from the MRI/CT scans. Measurements will be made of the image slice with the largest cross sectional area. Two orthogonal measures will be made to determine maximal AP and lateral dimensions. Progression of disease will be defined as a greater than 25% increase of largest cross sectional area by two orthogonal measurements, taking as reference the smallest sum recorded since the treatment started or the appearance of one or more new lesions.

Hydroxyurea: Hydroxyurea inhibits DNA synthesis by inhibition of ribonucleotide diphosphate reductase and is a well-known drug used for the treatment of a number of tumor types including head and neck tumors and chronic myelogenous leukemia. It has also been used as an adjuvant for antiretroviral treatment for patients with HIV and as a treatment for polycythemia vera, essential thrombocythemia and sickle cell disease.
Verapamil: Verapamil is another commonly used medication. It is used for the treatment of angina, hypertension, supraventricular arrhythmias, and migraine prophylaxis. Dosing with standard verapamil is 80-120 mg pox three times a day but the sustained release form can be given 120-480mg once or twice each day.

All Participants

Median Progression-free Survival Rates of the Treatment Population.

Overall Study

Dr. Randy Jensen

Cancer

Brain Cancer

Meningioma

Hydroxyurea inhibits DNA synthesis by inhibition of ribonucleotide diphosphate reductase and is a well-known drug used for the treatment of a number of tumor types including head and neck tumors and chronic myelogenous leukemia. It has also been used as an adjuvant for antiretroviral treatment for patients with HIV and as a treatment for polycythemia vera, essential thrombocythemia and sickle cell disease.

Hydroxyurea

Verapamil is another commonly used medication. It is used for the treatment of angina, hypertension, supraventricular arrhythmias, and migraine prophylaxis. Dosing with standard verapamil is 80-120 mg pox three times a day but the sustained release form can be given 120-480mg once or twice each day.

meningioma/kalium

Skull Base Reconstruction After Endonasal Cranio-endoscopic Resection Using Autologus Grafts

Combination of Hydroxyurea and Verapamil for Refractory Meningiomas

Täydellisin lääketieteellinen tietokanta tieteen tukemana