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patulin/syöpä

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ArtikkelitKliiniset tutkimuksetPatentit
11 tuloksia

In vitro antitumor activity of patulin on cervical and colorectal cancer cell lines.

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UNASSIGNED Patulin is a mycotoxin produced by some molds, especially Aspergillus and Penicilium, and is responsible for mycotoxicosis in animals and humans.There is still not very detailed data about the anti-cancer potency of patulin, but some reports demonstrated that it induces cellular apoptosis

The potential effect of patulin on mice bearing melanoma cells: an anti-tumour or carcinogenic effect?

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Mycotoxins are bioactive compounds that are noxious to human. Their effects on oncogenesis have been satisfactorily elucidated, and some of mycotoxins have been classified as carcinogenic to humans. Nevertheless, patulin (PAT) is considered by the International Agency of Research on Cancer as 'not

Patulin induces colorectal cancer cells apoptosis through EGR-1 dependent ATF3 up-regulation.

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Patulin is a fungal mycotoxin of Aspergilus and Penicillium that is commonly found in rotting fruits and exerts its potential toxic effect mainly by reactive oxygen species (ROS) generation. However, the effect of patulin on cancer cells as well as its intracellular mechanism has been controversial

Antitumor activity of patulin and structural analogs.

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A comparison between the cytotoxicity and the antitumor activity of patulin and five structural analogs (isopatulin, dehydroisopatulin, dimethylisopatulin, trimethylisopatulin and isopropylisopatulin) has been established. In vitro assays using L 1210 and P 388 cells showed that the structure of the

[Recent knowledge on the mechanism of action and metabolism of mycotoxins].

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By investigations on domestic and laboratory animals great progress was achieved in the clarification of the mechanism of action and of the metabolism of mycotoxins. The aflatoxins which inhibit the synthesis of RNA in the liver and which lead to a liver necrosis are all over the world of great

Highly Oxygenated Constituents from a Marine Alga-Derived Fungus Aspergillus giganteus NTU967

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Agar-based disc diffusion antimicrobial assay has shown that the ethyl acetate extract of the fermented broth of Aspergillus giganteus NTU967 isolated from Ulva lactuca exhibited significant antimicrobial activity in our preliminary screening of bioactive fungal strains.

Significance of Mycotoxins to Food Safety and Human Health 1,2.

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Mycotoxins are toxic substances produced by molds, which cause disease in animals or man. Acute diseases caused by mycotoxins are called mycotoxicoses. History has recorded several human disease outbreaks and numerous animal poisonings thought to be mycotoxicoses. The outbreak of Turkey X disease in

Analysis of in vitro chemoprevention of genotoxic damage by phytochemicals, as single agents or as combinations.

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Cancer chemoprevention with low-dose combinations of bioactive phytochemicals instead of single agents has been suggested to induce less toxicity and improve efficacy. In this study, we selected four plant food-based phytochemicals, viz. chlorogenic acid (CLA), pelargonidin (PEL), resveratrol (RES)

A highly fatal tremorgenic mycotoxicosis of cattle caused by Aspergillus clavatus.

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During February 1975, a tremorgenic neurotoxicosis decimated a herd of cattle in the northern Transvaal. This hitherto unidentified disease was characterized by hypersensitivity, incoordination, a peculiar stiff-legged gait of the hind legs, severe generalized tumors of the sketetal muscles,
Isothiocyanates (ITCs) are natural compounds derived from cruciferous vegetables produced by enzymatic conversion of metabolites called glucosinolates. They are potentially useful antimicrobial compounds for food applications have been shown to be promising agents against cancer in human cell

High-throughput chemical screens identify disulfiram as an inhibitor of human glioblastoma stem cells.

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Glioblastoma Multiforme (GBM) continues to have a poor patient prognosis despite optimal standard of care. Glioma stem cells (GSCs) have been implicated as the presumed cause of tumor recurrence and resistance to therapy. With this in mind, we screened a diverse chemical library of 2,000 compounds
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