Healthy normal weight (BMI 20-25) men 18-35 year. Intervention: The participants will take placebo or silica powder with specified doses administrated in vials and with instructions to mix with water as; Placebo (microcrystalline cellulose) day 1-5 Porous silica 1gx3 daily for day 6-9 Porous silica 2gx3 daily for day 10-14 Porous silica 3gx3 daily for day 15-21 Total study time 21 days

Obese otherwise healthy men (BMI 30-45) 18-35 year Intervention: The participants will take placebo or silica powder with specified doses administrated in vials and with instructions to mix with water as; Placebo (microcrystalline cellulose) day 1-5 Porous silica 1gx3 daily for day 6-9 Porous silica 2gx3 daily for day 10-14 Porous silica 3gx3 daily for day 15-21 The dose of Silica 3gx3 for additional 10 weeks Total study time 84 days

Safety Issues

The particle is rod shaped and approximately 1-3 x 0.4-0.5 micrometers with pore sizes in the range of 70-130 Ångström or 7-13 nanometer.

Porous silica

All participants starts with five days placebo run in period

Placebo (microcrystalline cellulose)

Safety Evaluation of Porous Silica in Men

Tolerability and Feasibility Evaluation of a Food Additive Based on Porous Silica Compounds for Future Weight Loss and Prevention of Obesity Related Co-morbidities

Evaluates by 5 graded questions of gastrointestinal habits and discomfort

Tests of Hemoglobin, calprotectin and elastase in feces

Vitamin and trace elements levels measured in blood

Triglycerides, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol in blood

Fasting glucose, insulin and hemoglobin A1c in blood

Alanine aminotransferase and aspartate aminotransferase in blood

Pernilla Danielsson

Principal Investigator

Karolinska Institutet

Sigrid Therapeutics AB, Sweden

Stockholm University

Diet Modification

2 flavonoid/caffeine capsules before breakfast, 2 capsules before lunch

Flavonoid, caffeine

2 placebo capsules before breakfast, 2 capsules before lunch

Placebo

Appalachian State University Human Performance Lab, North Carolina Research Campus

Influence of Flavonoids and Caffeine Supplementation on Resting Metabolism

A Randomized, Cross-Over Clinical Trial to Evaluate the Acute Effects of Mixed Flavonoid and Caffeine Ingestion on Energy Expenditure and Fat Oxidation in Healthy Adult Women

Energy expenditure (kilocalories) over 24 h in metabolic chamber with oxygen consumption and carbon dioxide production analyzers whereby energy expenditure is calculated from respiratory exchange data (oxygen consumption, carbon dioxide production) using standard equations

Fat oxidation (fat grams) over 24 h in metabolic chamber with oxygen consumption and carboh dioxide production analyzers whereby fat oxidation (grams/minute) is calculated from respiratory exchange data (oxygen consumption, carbon dioxide production) using standard equations

Appalachian State University

University of North Carolina, Chapel Hill

Prostate Cancer

Patients treated for prostate cancer by radical prostatectomy

Visceral adipose tissue specimen

Urology CHRU-TOURS

University Hospital

Uniersity Hospital

Structural Network on Prostate Cancer in the French Greater West Region

Réseau Structurant Sur le Cancer de la Prostate du Grand Ouest

Past dietary intake of essential fatty acids is quantified by measuring their concentration in white adipose tissue

Exposure to persistant organic pollutants (organochlorine chemicals, which are fat-soluble) is quantified by measuring the concentration in white adipose tissue

University Hospital, Tours

Institut National de la Santé Et de la Recherche Médicale, France

Nantes University Hospital

Rennes University Hospital

University Hospital, Angers

Poitiers University Hospital

Centre Hospitalier Universitaire de Pointe-a-Pitre

Study treatment will consist of BCP, three 1.2 g oral tablets (equivalent to 600 mg of BCP each) for 4 weeks, from cows immunized to insulin. Patients will be followed for safety monitoring for an additional 4 weeks.

silica/lihavuus

Safety Evaluation of Porous Silica in Men

Influence of Flavonoids and Caffeine Supplementation on Resting Metabolism

Structural Network on Prostate Cancer in the French Greater West Region

Bovine Colostrum for Patients With Non Alcoholic Fatty Liver Disease

Täydellisin lääketieteellinen tietokanta tieteen tukemana