[Association of rs966221 phosphodiesterase 4D gene's polymorphism with risk of myocardial infarction].

The aim of the paper was to study an association of rs966221 phosphodiesterase 4D (PDE4D) gene's polymorphism with risk of myocardial infarction (IM). One hundren sixty six persons were observed. The I (main) group included 97 patients with IM in anamnesis and the II (control) group consisted of 65 persons without IM. The study of polymorphism was performed by polymerase chain reaction with restriction of products. An increased frequency of TT genotype in the main group (20.6 %) comparing with controls (7.7 %; P = 0.026) was found. The differences were significant in men over 60 years old, having presence of arterial hypertension and signs of dyslipidemia.