Zhongguo zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban 2002-Jan

[Clinical and experimental study on treatment of acute cerebral infarction by zhongfeng no. II oral liquid].

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Heng-zhao Zhu

An Zheng

Dong Li

ARTICLE: 12585170

BioSeek: 12585170

Mots clés

superoxide dismutase

infarci

infarctus cérébral

glutamic acid

glutamic

glutathione

Abstrait

OBJECTIVE

To explore the effect and mechanism of Zhongfeng No. II Oral Liquid (ZF II) in treating acute cerebral infarction (CI).

METHODS

Randomly controlled clinical study was conducted in 160 patients with CI, they were treated with ZF II plus western medicine (treated group) and western medicine alone (control group) respectively. The animal model of CI was made by unilaterally common carotid artery ligation in 45 Mongolian gerbil, and they were divided into the model group, the normal saline group and ZF II group.

RESULTS

ZF II could improve the TCM Syndrome, neuro-function and cerebral blood circulation in CI patients. Experimental study showed that ZF II could significantly inhibit the release of glutamic acid in 6 hrs (P < 0.05), maintain the level of superoxide dismutase (SOD) and glutathione, and scavenge the free radicals effectively.

CONCLUSIONS

ZF II could improve the function of brain tissue, and is worth developing and applying in treating CI.