Congenital pulmonary malformations: metabolomic profile of lung phenotype in infants.
Mots clés
Abstrait
BACKGROUND
The main hydrosoluble metabolites in three different human congenital pulmonary malformations are described by nuclear magnetic resonance (NMR) spectroscopy.
METHODS
Bronchogenic cyst (BC), congenital lobar emphysema (CLE) and intrapulmonary sequestration (IPS), were analyzed with respect to a control sample. The extracted metabolites were submitted to high-resolution (1)H NMR-spectroscopy.
RESULTS
Congenital lung malformations showed free choline, phosphocoline and myoinositol high levels. IPS and CLE were found increased in lactic acid/glucose ratio. Lactic acid and glucose values resulted to be more elevated in control sample.
CONCLUSIONS
Congenital lung lesions showed different metabolomic profiles useful for early diagnosis.